Altered Risk of Incident Gout According to Changes in Metabolic Syndrome Status: A Nationwide, Population-Based Cohort Study of 1.29 Million Young Men

被引:8
|
作者
Eun, Yeonghee [1 ]
Han, Kyungdo [2 ]
Lee, Seung Woo [3 ]
Kim, Kyunga [4 ,5 ]
Kang, Seonyoung [6 ]
Lee, Seulkee [6 ]
Cha, Hoon-Suk [6 ]
Koh, Eun-Mi [6 ]
Kim, Hyungjin [6 ,7 ]
Lee, Jaejoon [6 ]
机构
[1] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Rheumatol,Sch Med, Seoul, South Korea
[2] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea
[3] Catholic Univ Korea, Coll Med, Dept Biomed & Hlth Sci, Seoul, South Korea
[4] Sungkyunkwan Univ, Res Inst Future Med, Stat & Data Ctr, Samsung Med Ctr, Seoul, South Korea
[5] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Dept Digital Hlth, Seoul, South Korea
[6] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Med, Seoul, South Korea
[7] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Med Humanities, Seoul, South Korea
关键词
DIAGNOSIS; OBESITY; TRENDS; MANIFESTATIONS; HYPERURICEMIA; TRIGLYCERIDES; HYPERTENSION; PREVALENCE; ARTHRITIS; GLUCOSE;
D O I
10.1002/art.42381
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. Few data are available on whether changes in metabolic syndrome affect incident gout. This study was undertaken to assess associations between metabolic syndrome status and incident gout, as well as changes in the clinical characteristics of metabolic syndrome and incident gout, in a cohort of young men. Methods. This nationwide, population-based cohort study included 20-39-year-old men who participated in serial health check-ups. The outcome, incident gout, was defined according to the claims database diagnostic code for gout. Associations among changes in metabolic syndrome status and incident gout were analyzed using Cox proportional hazards models. Results. Among 1,293,166 individuals, 18,473 were diagnosed as having gout (incidence rate 3.36 per 1,000 person-years). Subjects who had chronic metabolic syndrome (defined as metabolic syndrome at all 3 health check-ups) had a nearly 4-fold higher risk of incident gout compared to subjectswho did not havemetabolic syndrome at any of the 3 health check-ups (adjusted hazard ratio [HRadj] 3.82 [95% confidence interval (95% CI) 3.67-3.98]). Development of metabolic syndrome more than doubled the risk of incident gout (HRadj 2.31 [95% CI 2.20-2.43]). Conversely, recovery from metabolic syndrome reduced the risk of incident gout by nearly half (HRadj 0.52 [95% CI 0.49-0.56]). Among metabolic syndrome components, changes in elevated triglycerides (development of elevated triglycerides, HRadj 1.74 [95% CI 1.66-1.81]; recovery from elevated triglycerides, HRadj 0.56 [95% CI 0.54-0.59]) and abdominal obesity (development of abdominal obesity, HRadj 1.94 [95% CI 1.85-2.03]; recovery from abdominal obesity, HRadj 0.69 [95% CI 0.64-0.74]) showed the greatest association with altered risk of incident gout. Associations between changes in the status and clinical characteristics of metabolic syndrome and incident gout were more pronounced in subjects ages 20-29 years compared to those ages 30-39 years, and in subjects who were underweight or who had a normal weight. Conclusion. Changes in the status and clinical characteristics of metabolic syndrome were associated with altered risk of incident gout. These results suggest that metabolic syndrome is a modifiable risk factor for gout.
引用
收藏
页码:806 / 815
页数:10
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