The role of the cytokine TNF-α in choroidal neovascularization: a systematic review

被引:5
|
作者
Papadopoulos, Zois [1 ]
机构
[1] European Univ Cyprus, Sch Med, Nicosia, Cyprus
关键词
TUMOR-NECROSIS-FACTOR; COMPLEMENT FACTOR-B; MACULAR DEGENERATION; INTRAVITREAL INFLIXIMAB; AQUEOUS-HUMOR; GENE POLYMORPHISMS; PLASMA-LEVELS; IFN-GAMMA; ACTIVATION; GLYCATION;
D O I
10.1038/s41433-023-02634-5
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
TNF-& alpha; is a multifunctional cytokine produced by macrophages and T cells. This proinflammatory substance is considered to play a crucial role in the inflammatory process associated with age-related macular degeneration (AMD). The current review aimed to describe evidence for an association between TNF-& alpha; and AMD reported in various studies. The MEDLINE, Embase, PubMed and Global Health databases were systematically searched to identify studies that investigated the role of TNF-& alpha; in AMD. A total of 24 studies were deemed eligible for the review. To better understand and integrate the evidence, the studies were categorised into four major groups in relation to the role of TNF-& alpha; in AMD: (1) those examining biological signalling pathways through which TNF-& alpha; exerts its effect; (2) investigating levels of TNF-& alpha;; (3) exploring the genetics underlying the role of TNF-& alpha;; and (4) assessing anti-TNF-& alpha; agents as potential treatments for AMD. TNF-& alpha; is thought to directly contribute to choroidal neovascularization (CNV) enhancement and has been shown to exert its effect by augmenting the inflammatory response through other signalling pathways. Additionally, different genes have been found to be associated with activities linked to TNF-& alpha; in AMD. Overall, measurement of systemic and local levels of TNF-& alpha; has not yielded consistent findings, with variable conclusions for the role of anti-TNF-& alpha; agents in remission of AMD symptoms. The role of TNF-& alpha; in neovascular AMD is not clear, and not all anti-TNF-& alpha; agents are safe. The potential of this cytokine in atrophic AMD has not been examined. Future studies should address these unresolved questions.
引用
收藏
页码:25 / 32
页数:8
相关论文
共 50 条
  • [21] Functional role of TLR in choroidal neovascularization
    Ng, Yin Shan Eric
    Ju, Meihua
    Iwata, Daiju
    Foxton, Richard
    Bunker, Shannon
    Belich, Monica
    Gough, Gerald
    Adamson, Peter S.
    Shima, David T.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (13)
  • [22] Role of complement system in choroidal neovascularization
    Bora, PS
    Sohn, JH
    Kang, SG
    Bora, NS
    Kaplan, HJ
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2002, 43 : U293 - U293
  • [23] TNF-α mediates choroidal neovascularization by upregulating VEGF expression in RPE through ROS-dependent β-catenin activation
    Wang, Haibo
    Han, Xiaokun
    Wittchen, Erika S.
    Hartnett, M. Elizabeth
    MOLECULAR VISION, 2016, 22 : 116 - 128
  • [24] An Angiogenic Role for Adrenomedullin in Choroidal Neovascularization
    Sakimoto, Susumu
    Kidoya, Hiroyasu
    Kamei, Motohiro
    Naito, Hisamichi
    Yamakawa, Daishi
    Sakaguchi, Hirokazu
    Wakabayashi, Taku
    Nishida, Kohji
    Takakura, Nobuyuki
    PLOS ONE, 2013, 8 (03):
  • [25] Critical Role of TNF-α-Induced Macrophage VEGF and iNOS Production in the Experimental Corneal Neovascularization
    Lu, Peirong
    Li, Longbiao
    Liu, Gaoqin
    Baba, Tomohisa
    Ishida, Yuko
    Nosaka, Mizuho
    Kondo, Toshikazu
    Zhang, Xueguang
    Mukaida, Naofumi
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2012, 53 (07) : 3516 - 3526
  • [26] The Role of TNF-α in Alzheimer's Disease: A Narrative Review
    Plantone, Domenico
    Pardini, Matteo
    Righi, Delia
    Manco, Carlo
    Colombo, Barbara Maria
    De Stefano, Nicola
    CELLS, 2024, 13 (01)
  • [27] Safety of TNF-α inhibitors during IBD pregnancy: a systematic review
    Ole Haagen Nielsen
    Edward V Loftus Jr
    Tine Jess
    BMC Medicine, 11
  • [28] Safety of TNF-α inhibitors during IBD pregnancy: a systematic review
    Nielsen, Ole Haagen
    Loftus, Edward V., Jr.
    Jess, Tine
    BMC MEDICINE, 2013, 11
  • [29] Up-regulation of BDNF in Astrocytes by TNF-α: A Case for the Neuroprotective Role of Cytokine
    Ramendra N. Saha
    Xiaojuan Liu
    Kalipada Pahan
    Journal of Neuroimmune Pharmacology, 2006, 1 : 212 - 222
  • [30] Up-regulation of BDNF in Astrocytes by TNF-α: A Case for the Neuroprotective Role of Cytokine
    Saha, Ramendra N.
    Liu, Xiaojuan
    Pahan, Kalipada
    JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2006, 1 (03) : 212 - 222