Current clinical findings of acute neurological syndromes after SARS-CoV-2 infection

被引:1
|
作者
Wang, Minjin [1 ,2 ,3 ]
Wang, Jierui [1 ,3 ]
Ren, Yan [2 ]
Lu, Lu [1 ,3 ]
Xiong, Weixi [1 ,3 ]
Li, Lifeng [4 ]
Xu, Songtao [5 ]
Tang, Meng [2 ]
Yuan, Yushang [2 ]
Xie, Yi [2 ]
Li, Weimin [6 ]
Chen, Lei [1 ,3 ]
Zhou, Dong [1 ,3 ]
Ying, Binwu [2 ]
Li, Jinmei [1 ,3 ]
机构
[1] Sichuan Univ, Dept Neurol, West China Hosp, Chengdu, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, Dept Lab Med, Chengdu, Sichuan, Peoples R China
[3] Sichuan Univ, Inst Brain Sci & Brain Inspired Technol, West China Hosp, Chengdu, Sichuan, Peoples R China
[4] Genskey Med Biotechnol Co Ltd, Beijing, Peoples R China
[5] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China
[6] Sichuan Univ, West China Hosp, Dept Resp & Crit Care Med, Chengdu, Sichuan, Peoples R China
来源
MEDCOMM | 2024年 / 5卷 / 03期
基金
中国国家自然科学基金;
关键词
central nerve injury; Neuro-COVID; neurological syndromes; neurotropic invasion; SARS-CoV-2; COVID-19; MANIFESTATIONS;
D O I
10.1002/mco2.508
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Neuro-COVID, a condition marked by persistent symptoms post-COVID-19 infection, notably affects various organs, with a particular focus on the central nervous system (CNS). Despite scant evidence of SARS-CoV-2 invasion in the CNS, the increasing incidence of Neuro-COVID cases indicates the onset of acute neurological symptoms early in infection. The Omicron variant, distinguished by heightened neurotropism, penetrates the CNS via the olfactory bulb. This direct invasion induces inflammation and neuronal damage, emphasizing the need for vigilance regarding potential neurological complications. Our multicenter study represents a groundbreaking revelation, documenting the definite presence of SARS-CoV-2 in the cerebrospinal fluid (CSF) of a significant proportion of Neuro-COVID patients. Furthermore, notable differences emerged between RNA-CSF-positive and negative patients, encompassing aspects such as blood-brain barrier integrity, extent of neuronal damage, and the activation status of inflammation. Despite inherent limitations, this research provides pivotal insights into the intricate interplay between SARS-CoV-2 and the CNS, underscoring the necessity for ongoing research to fully comprehend the virus's enduring effects on the CNS. The findings underscore the urgency of continuous investigation Neuro-COVID to unravel the complexities of this relationship, and pivotal in addressing the long-term consequences of COVID-19 on neurological health. Phylogeny and genomic features of 10 SARS-CoV-2 isolates. Notably, nine cerebrospinal fluid (CSF) samples and one matched nasopharyngeal swab (NPS) sample displayed substantial coverage of the entire SARS-CoV-2 genome, meeting the criteria of 10x >= 90% and 100x >= 60% against the original Wuhan SARS-CoV-2 genome. The phylogenetic tree, crafted using RAxML and visualized with iTOL, highlights consensus genomes from each analyzed sample. Sample types are denoted by the yellow square, and distinct Pango lineages, identified by Nextclade, are represented by the blue square. For clarity, three bubble plots showcase sequencing coverage (1x, 10x, and 100x) for each sample in comparison with the first Wuhan SARS-CoV-2 genome. Furthermore, the figure illustrates mapping and semi-log depth of coverage of sequencing reads for each sample against the initial Wuhan SARS-CoV-2 genome, providing a comprehensive depiction of the genomic attributes of the examined isolates. # image
引用
收藏
页数:17
相关论文
共 50 条
  • [41] ANTI-GANGLIOSIDE ANTIBODIES AND NEUROLOGICAL DISORDERS AFTER SARS-COV-2 INFECTION
    Uchibori, Ayumi
    Ichikawa, Yaeko
    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2024, 29 : S128 - S129
  • [42] Arthritis after SARS-CoV-2 infection
    Baimukhamedov, Chokan
    Barskova, Tatiana
    Matucci-Cerinic, Marco
    LANCET RHEUMATOLOGY, 2020, 3 (05): : E324 - E325
  • [43] Colitis After SARS-CoV-2 Infection
    Gill, Rajwinder
    Siau, Evan
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (07)
  • [44] Operations after SARS-CoV-2 Infection
    不详
    CHIRURG, 2021, 92 (10): : 906 - 906
  • [45] SLE AFTER SARS-COV-2 INFECTION
    Ejimone, Fortunate
    Bashir, Khalid
    AMERICAN JOURNAL OF KIDNEY DISEASES, 2022, 79 (04) : S116 - S116
  • [46] Diabetes after SARS-CoV-2 infection
    Al-Aly, Ziyad
    LANCET DIABETES & ENDOCRINOLOGY, 2023, 11 (01): : 11 - 13
  • [47] Neurological Manifestations of SARS-CoV-2 Infection in Type 2 Diabetes
    Thepmankorn, Parisorn
    Heshmati, Keyvan
    Ruane, Claire
    Shafiq, Basit
    Adam, Tarek
    Adam, Nabil
    Souayah, Nizar
    NEUROLOGY, 2021, 96 (15)
  • [48] SARS-CoV-2 Infection in Patients with Lung Cancer: Current Clinical Context
    Isea de la Vina, Jesus
    Ortega Granados, Ana Laura
    Alcazar-Navarrete, Bernardino
    ARCHIVOS DE BRONCONEUMOLOGIA, 2020, 56 (10): : 684 - 684
  • [49] Electrocardiographic findings in young competitive athletes during acute SARS-CoV-2 infection
    Petek, Bradley J.
    Moulson, Nathaniel
    Baggish, Aaron L.
    Drezner, Jonathan A.
    Harmon, Kimberly G.
    Klein, Christian F.
    Kliethermes, Stephanie A.
    Patel, Manesh R.
    Churchill, Timothy W.
    JOURNAL OF ELECTROCARDIOLOGY, 2022, 72 : 13 - 15
  • [50] Acute Clinical Syndromes and Suspicion of SARS-CoV-2 Infection: The Experience of a Single Romanian Center in the Early Pandemic Period
    Haliga, Raluca Ecaterina
    Sorodoc, Victorita
    Lionte, Catalina
    Petris, Ovidiu Rusalim
    Bologa, Cristina
    Coman, Adorata Elena
    Vata, Luminita Gina
    Puha, Gabriela
    Dumitrescu, Gabriela
    Sirbu, Oana
    Stoica, Alexandra
    Ceasovschih, Alexandr
    Constantin, Mihai
    Nicoleta Catana, Andreea
    Jaba, Elisabeta
    Sorodoc, Laurentiu
    MEDICINA-LITHUANIA, 2021, 57 (02): : 1 - 12