A plus AVD for Treatment of Hodgkin Lymphoma Variant of Richter's Transformation

被引：0
|
作者：
Heyman, Benjamin [1 ]
Choi, Michael [2 ]
Kipps, Thomas J. [3 ]
机构：
[1] UC San Diego Moores Canc Ctr, Dept Med, Div Regenerat Med, UC San Diego, La Jolla, CA 92093 USA
[2] Dept Med, Div Hematol Oncol, UC San Diego, La Jolla, CA 92093 USA
[3] Ctr Novel Therapeut, Dept Med, Div Hematol Oncol, UC San Diego, La Jolla, CA 92093 USA
来源：
CASE REPORTS IN HEMATOLOGY | 2024年 / 2024卷
关键词：
CHRONIC LYMPHOCYTIC-LEUKEMIA; BRENTUXIMAB VEDOTIN; PHASE-II; CHEMOTHERAPY; VENETOCLAX; OUTCOMES; THERAPY; DISEASE; ABVD; MOPP;
D O I：
10.1155/2024/7612622
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hodgkin lymphoma variant of Richter's transformation (HvRT) is a rare complication for patients with chronic lymphocytic leukemia (CLL), with an overall poor prognosis. We present the first known case series of patients with HvRT treated with the combination of brentuximab vedotin, doxorubicin, vinblastine, and dacarbazine (A + AVD). In our series of 4 patients, two patients treated with A + AVD for HvRT had durable remissions of 40 and 42 months, while two patients had disease progression and ultimately died. Continued investigation into the optimal management for patients with HvRT is still needed.
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页数：8
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