Coptisine Reduces the Progression of Cervical Cancer Through Induction of Autophagy

被引：0
|
作者：
Zhao, Yaping [1 ]
Gao, Xia [2 ]
机构：
[1] Jinchang Peoples Hosp, Dept Obstet & Gynaecol, Hexibao Ward, Jinchang 737100, Gansu, Peoples R China
[2] Pengzhou Peoples Hosp, Dept Pathol, Chengdu 611930, Sichuan, Peoples R China
来源：
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2023年 / 21卷 / 01期
关键词：
Autophagy; Cervical cancer; Coptisine; PI3K/AKT/mTOR pathway; RHIZOMA-COPTIDIS; CELL-MIGRATION; APOPTOSIS; PHOSPHORYLATION; ALKALOIDS; ASSAY; TIME;
D O I：
10.37290/ctnr2641-452X.21:18-24
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The regulatory role of coptisine on autophagy in cervical cancer cells (in HcerEpic, HeLa, and SiHa) was examined by assessment of cell viability, colony formation, and apoptosis. Coptisine, in a dose-dependent fashion, significantly inhibited cervical cancer cell viability as measured by cell proliferation, transwell, and TUNEL assays. Coptisine inhibited the levels of p62 and Bcl-2, whilst it promoted the accumulation of Atg5, LC3./LC3. and Bax. These data taken together suggest that coptisine inhibits the progression of cervical cancer cells by enhancing autophagy through suppression of the PI3K/AKT/ mTOR pathway. This represents a theoretical foundation for developing novel cervical cancer treatments.
引用
收藏
页码：18 / 24
页数：7
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