Coptisine Reduces the Progression of Cervical Cancer Through Induction of Autophagy

被引：0

作者：

Zhao, Yaping ^{[1
]}

Gao, Xia ^{[2
]}

机构：

[1] Jinchang Peoples Hosp, Dept Obstet & Gynaecol, Hexibao Ward, Jinchang 737100, Gansu, Peoples R China

[2] Pengzhou Peoples Hosp, Dept Pathol, Chengdu 611930, Sichuan, Peoples R China

来源：

CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2023年 / 21卷 / 01期

关键词：

Autophagy; Cervical cancer; Coptisine; PI3K/AKT/mTOR pathway; RHIZOMA-COPTIDIS; CELL-MIGRATION; APOPTOSIS; PHOSPHORYLATION; ALKALOIDS; ASSAY; TIME;

D O I：

10.37290/ctnr2641-452X.21:18-24

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The regulatory role of coptisine on autophagy in cervical cancer cells (in HcerEpic, HeLa, and SiHa) was examined by assessment of cell viability, colony formation, and apoptosis. Coptisine, in a dose-dependent fashion, significantly inhibited cervical cancer cell viability as measured by cell proliferation, transwell, and TUNEL assays. Coptisine inhibited the levels of p62 and Bcl-2, whilst it promoted the accumulation of Atg5, LC3./LC3. and Bax. These data taken together suggest that coptisine inhibits the progression of cervical cancer cells by enhancing autophagy through suppression of the PI3K/AKT/ mTOR pathway. This represents a theoretical foundation for developing novel cervical cancer treatments.

引用

页码：18 / 24

页数：7

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