Sexual dysfunction in women with systemic autoimmune rheumatic disorders: a systematic review and meta-analysis

Objectives In women with systemic autoimmune rheumatic diseases (SARDs), female sexual dysfunction (SD) remains underestimated. We aimed to explore the prevalence and correlates of SD in females with SARDs. Methods We performed a systematic review and meta-analysis of studies assessing the prevalence of SD and the pooled Female Sexual Function Index (FSFI) scores in this setting (PROSPERO: CRD42021287346). We searched PubMed, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) databases and grey literature until February 2022. We evaluated the quality of the selected records using the Hoy Risk of Bias tool. A random-effects meta-analysis of proportions with the double arcsine transformation was conducted. Subgroup and sensitivity analyses, as well as meta-regression of important correlates, were conducted. Results We included 68 studies with 5457 females diagnosed with a SARD (mean age: 43.7 [12.9] years). The overall SD prevalence was 63% (95% CI: 56, 69%, I-2 = 94%) and the overall FSFI total score was 19.7 points (95% CI: 18.4, 21, I-2 = 97%). Including only sexually active females, the SD prevalence was estimated as 60% (95% CI: 53, 67%, I-2 = 88%), whereas the FSFI total score was 22 points (95% CI: 20.8, 23.1, I-2 = 93%). Across the different SARDs, women with Sjogren's syndrome and systemic sclerosis reported the highest levels of SD (74%, 95% CI: 58, 87%, I-2 = 84% and 69%, 95% CI: 54, 83%, I-2 = 94%, respectively). Conclusion Sexual function in females with SARDs seems to be severely impaired, irrespective of the type of SARD. Screening and treatment of SD in females with SARDs should become an integral part of healthcare clinical practice.