Investigating TSPO levels in occupation-related posttraumatic stress disorder

被引：0
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作者：
Watling, Sarah E. E. [1 ,2 ]
Gill, Talwinder [1 ,2 ]
Gaudette, Erin V. V.
Richardson, J. Don [6 ,7 ,8 ,9 ]
McCluskey, Tina [2 ,3 ]
Tong, Junchao [2 ,3 ,4 ]
Meyer, Jeffrey H. H. [5 ]
Warsh, Jerry [1 ,2 ,3 ,4 ,5 ]
Jetly, Rakesh [10 ,11 ,12 ]
Hutchison, Michael G. G. [13 ,14 ,15 ]
Rhind, Shawn G. G. [13 ,16 ]
Houle, Sylvain [2 ,3 ,4 ]
Kish, Stephen J. J. [5 ]
Boileau, Isabelle [1 ,2 ,3 ,4 ]
机构：
[1] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[2] Brain Hlth Imaging Ctr, Ctr Addict & Mental Hlth, Toronto, ON, Canada
[3] Campbell Mental Hlth Res Inst, Ctr Addict & Mental Hlth, Toronto, ON, Canada
[4] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
[5] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada
[6] Lawson Hlth Res Inst, MacDonald Franklin OSI Res Ctr, London, ON, Canada
[7] Univ Western Ontario, Dept Psychiat, London, ON, Canada
[8] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada
[9] St Josephs Hlth Care, Parkwood Inst, London, ON, Canada
[10] Canadian Forces Hlth Serv, Directorate Mental Hlth, Ottawa, ON, Canada
[11] Univ Ottawa, Fac Med, Dept Psychiat, Ottawa, ON, Canada
[12] Dalhousie Univ, Fac Med, Dept Psychiat, Halifax, NS, Canada
[13] Univ Toronto, Fac Kinesiol & Phys Educ, Toronto, ON, Canada
[14] Univ Toronto, Fac Kinesiol & Phys Educ, David L MacIntosh Sport Med Clin, Toronto, ON, Canada
[15] Michaels Hosp, Keenan Res Ctr Biomed Sci St, Toronto, ON, Canada
[16] Toronto Res Ctr, Def Res & Dev Canada, Toronto, ON, Canada
来源：
SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期
关键词：
ANXIETY-LIKE BEHAVIOR; TRANSLOCATOR PROTEIN; MICROGLIAL ACTIVATION; 18; KDA; PET; NEUROINFLAMMATION; BRAIN; MACROPHAGES; ASTROCYTES; PREVENTS;
D O I：
10.1038/s41598-023-31327-y
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Microglia are immune brain cells implicated in stress-related mental illnesses including posttraumatic stress disorder (PTSD). Their role in the pathophysiology of PTSD, and on neurobiological systems that regulate stress, is not completely understood. We tested the hypothesis that microglia activation, in fronto-limbic brain regions involved in PTSD, would be elevated in participants with occupation-related PTSD. We also explored the relationship between cortisol and microglia activation. Twenty participants with PTSD and 23 healthy controls (HC) completed positron emission tomography (PET) scanning of the 18-kDa translocator protein (TSPO), a putative biomarker of microglia activation using the probe [F-18]FEPPA, and blood samples for measurement of cortisol. [F-18]FEPPA V-T was non-significantly elevated (6.5-30%) in fronto-limbic regions in PTSD participants. [F-18]FEPPA V-T was significantly higher in PTSD participants reporting frequent cannabis use compared to PTSD non-users (44%, p = 0.047). Male participants with PTSD (21%, p = 0.094) and a history of early childhood trauma (33%, p = 0.116) had non-significantly higher [F-18]FEPPA V-T. Average fronto-limbic [F-18]FEPPA V-T was positively related to cortisol (r = 0.530, p = 0.028) in the PTSD group only. Although we did not find a significant abnormality in TSPO binding in PTSD, findings suggest microglial activation might have occurred in a subgroup who reported frequent cannabis use. The relationship between cortisol and TSPO binding suggests a potential link between hypothalamic-pituitary-adrenal-axis dysregulation and central immune response to trauma which warrants further study.
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页数：11
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