Membranous nephropathy with systemic light-chain amyloidosis of remission after rituximab therapy: A case report

被引：0
|
作者：
Zhang, Jiao [1 ]
Wang, Xu [2 ]
Zou, Gu-Ming [2 ]
Li, Jia-Yi [2 ]
Li, Wen-Ge [2 ,3 ]
机构：
[1] Beijing Univ Chinese Med, Beijing 100029, Peoples R China
[2] China Japan Friendship Hosp, Dept Nephrol, Beijing, Peoples R China
[3] China Japan Friendship Hosp, Dept Nephrol, 2 Yinghuayuan East St, Beijing 100029, Peoples R China
来源：
WORLD JOURNAL OF CLINICAL CASES | 2023年 / 11卷 / 23期
关键词：
Amyloidosis; Membranous nephropathy; Phospholipase A2 receptors; Rituximab; Renal biopsy; Case report; STAGING SYSTEM; AL;
D O I：
10.12998/wjcc.v11.i23.5538
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
BACKGROUND About 70%-80% of patients with primary membranous nephropathy (MN) have phospholipase A2 receptor (PLA2R) in renal tissue. Systemic light-chain (AL) amyloidosis is the most common type of amyloidosis. MN complicated with amyloidosis is rare.CASE SUMMARY A 48-year-old Chinese male presented with nephrotic syndrome, positive serum PLA2R antibody, and positive serum and urine IgG-lambda type M-protein, with a normal ratio of serum-free light-chain level. The patient was diagnosed with MN accompanied by AL amyloidosis. He was treated with rituximab with glucocorticoids and CyBorD regimen of chemotherapy. After 21 mo of follow-up, the patient achieved complete remission regarding nephrotic syndrome without adverse effects of chemotherapy.CONCLUSION We report a case of PLA2R-related MN complicated with primary AL amyloidosis only with renal involvement and successfully treated with rituximab, glucocorticoids and chemotherapy.
引用
收藏
页码：5538 / 5546
页数：9
相关论文
共 50 条
  • [41] Longitudinal Clinical Outcomes with Membranous-Like Nephropathy with Monoclonal Light-Chain Deposition: A Case Series
    Park, Elaine
    McMahon, Blaithin A.
    Zou Guangchen
    Atta, Mohamed G.
    Teruel, Benjamin R.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2024, 35 (10):
  • [42] A case of light-chain amyloidosis in stomach and small intestine
    Guan, Wenhao
    Song, Jiadong
    Dong, Yang
    ASIAN JOURNAL OF SURGERY, 2025, 48 (01) : 965 - 966
  • [43] Treatment of membranous nephropathy with crescent nephritis by rituximab: A case report
    Zhang, Fan
    Yang, Yiya
    Chen, Yinyin
    Chen, Ying
    Yin, Wei
    Liang, Yumei
    Luo, Xun
    MEDICINE, 2022, 101 (37) : E30663
  • [44] Predictors of early treatment failure following initial therapy for systemic immunoglobulin light-chain amyloidosis
    Tandon, Nidhi
    Sidana, Surbhi
    Rajkumar, S. Vincent
    Dispenzieri, Angela
    Gertz, Morie A.
    Lacy, Martha Q.
    Kyle, Robert A.
    Buadi, Francis K.
    Dingli, David
    Hayman, Suzanne R.
    Fonder, Amie L.
    Hobbs, Miriam A.
    Gonsalves, Wilson I.
    Kapoor, Prashant
    Hwa, Yi Lisa
    Leung, Nelson
    Go, Ronald S.
    Lust, John A.
    Russell, Stephen J.
    Zeldenrust, Steven R.
    Kumar, Shaji K.
    AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 2017, 24 (03): : 183 - 188
  • [45] Outcome of first-line therapy in patients with systemic light-chain amyloidosis: A multicentre analysis
    Fernandez, Ruben
    Silva-Soto, Ana
    Muniz, Sara
    Pilar Gonzalez, Ana
    Ramirez Payer, Angel
    Bermudez, Arancha
    Taboada, Francisco
    Chamorro, Cristina
    Moran, Marlen
    Robles, Veronica
    Sanchez, Sara
    Torres, Juan
    Dominguez, Francisco
    Alberto Davalos, Carlos
    Alvarez, Alba
    Gonzalez, Segundo
    Cepeda, Javier
    Fernandez, Carmen
    Gonzalez, Esther
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 (10): : E333 - E334
  • [46] ASSOCIATION OF SYSTEMIC LIGHT-CHAIN DEPOSITION DISEASE AND AMYLOIDOSIS - A REPORT OF 3 PATIENTS WITH RENAL INVOLVEMENT
    JACQUOT, C
    SAINTANDRE, JP
    TOUCHARD, G
    NOCHY, D
    DAUZACDELAMARTINIE, C
    ORIOL, R
    DRUET, P
    BARIETY, J
    CLINICAL NEPHROLOGY, 1985, 24 (02) : 93 - 98
  • [47] A case of Membranous Nephropathy with Light Chain Restricted Deposit
    Konda, Raghunandan
    Cook, Jared
    Chandramohan, Deepak
    JOURNAL OF INVESTIGATIVE MEDICINE, 2024, 72 (06)
  • [48] Coexistence of variant-type transthyretin and immunoglobulin light-chain amyloidosis: a case report
    Eda, Yuko
    Ishii, Shunsuke
    Onagi, Suzuho
    Katoh, Nagaaki
    Ako, Junya
    EUROPEAN HEART JOURNAL-CASE REPORTS, 2024, 8 (06)
  • [49] A risk stratification for systemic immunoglobulin light-chain amyloidosis with renal involvement
    Li, Ting
    Huang, Xianghua
    Wang, Qingwen
    Zhao, Liang
    Ren, Guisheng
    Chen, Wencui
    Zheng, Chunxia
    Zhou, Minlin
    Jiang, Qi
    Yin, Ru
    Liu, Zhihong
    BRITISH JOURNAL OF HAEMATOLOGY, 2019, 187 (04) : 459 - 469
  • [50] Systemic immunoglobulin light-chain amyloidosis presenting hematochezia as the initial symptom
    Kon T.
    Nakagawa N.
    Yoshikawa F.
    Haba K.
    Kitagawa N.
    Izumi M.
    Kumazaki S.
    Ishida S.
    Aikawa R.
    Clinical Journal of Gastroenterology, 2016, 9 (4) : 243 - 251
12345