Antifungal activity against Candida albicans of methyl 3,5-dinitrobenzoate loaded nanoemulsion

被引：4

作者：

Duarte, Allana Brunna Sucupira ^{[1
]}

Perez-Castillo, Yunierkis ^{[2
]}

Alves, Danielle da Nobrega ^{[3
]}

de Castro, Ricardo Dias ^{[3
]}

de Souza, Rafael Limongi ^{[4
]}

de Sousa, Damiao Pergentino ^{[5
]}

Oliveira, Elquio Eleamen ^{[4
]}

机构：

[1] Univ Fed Paraiba, Post Grad Program Nat & Synthet Bioact Prod, Joao Pessoa, Brazil

[2] Univ Las Amer, Escuela Ciencias Fis & Matemat, Biocheminformat Res Grp, Quito, Ecuador

[3] Univ Fed Paraiba, Dept Clin & Social Dent, Lab Expt Pharmacol & Cell Culture, Joao Pessoa, Brazil

[4] State Univ Paraiba, Lab Synth & Drug Delivery, Joao Pessoa, Brazil

[5] Univ Fed Paraiba, Dept Pharmaceut Sci, Joao Pessoa, Brazil

来源：

BRAZILIAN JOURNAL OF MICROBIOLOGY | 2024年 / 55卷 / 01期

关键词：

3,5-dinitrobenzoic acid; Antifungal activity; Candida albicans; Molecular docking; Nanoemulsion; ESSENTIAL OIL; SIMULATIONS; MODE; ULTRASONICATION; DERIVATIVES; VALIDATION; GENERATION; ALGORITHM; CARVACROL; SYSTEM;

D O I：

10.1007/s42770-023-01214-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The objective of this study was to evaluate the antifungal activity of free methyl 3,5 dinitrobenzoate (MDNB) and its nanoemulsion (MDNB-NE) against strains of Candida albicans. Additionally, a molecular modeling study was also carried out to propose the mechanism of action and toxicity of MDNB. These results demonstrated the MDNB-NE presented a droplet size of 181.16 +/- 3.20 nm and polydispersity index of 0.30 +/- 0.03. MDNB and MDNB-NE inhibited the growth of all strains with minimum inhibitory concentrations of 0.27-1.10 mM. The biological results corroborated the molecular model, which pointed to a multi-target antifungal mechanism of action for MDNB in C. albicans. The study could serve as a basis for further research involving compounds with nitro groups with antifungal.

引用

页码：25 / 39

页数：15

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