Fumarate disarms CD8+T cells against cancer

被引：0

作者：

Nezi, Luigi ^{[1
]}

Manzo, Teresa ^{[1
]}

机构：

[1] Ist Europeo Oncol IRCCS, Dept Expt Oncol, Milan, Italy

来源：

CELL METABOLISM | 2023年 / 35卷 / 06期

关键词：

D O I：

10.1016/j.cmet.2023.05.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The composition of nutrients in the tumor microenvironment is a key determinant of anti-tumor CD8(+) T cell response. In this issue of Cell Metabolism, Jiang and colleagues unveil that tumor-derived fumarate dampens TCR signaling in CD8(+) T cells, resulting in defective activation, loss of effector functions, and associated failure of tumor control.

引用

页码：907 / 909

页数：3

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