Palforzia for Peanut Allergy: A Narrative Review and Update on a Novel Immunotherapy

被引:4
|
作者
Borne, Grant E. [1 ]
Daniel, Charles P. [1 ]
Wagner, Maxwell J. [1 ]
Plaisance, Connor J. [1 ]
Nolen, Alexandra [1 ]
Kelkar, Rucha A. [2 ]
Ahmadzadeh, Shahab [3 ]
Myrcik, Dariusz [4 ]
Shekoohi, Sahar [3 ]
Kaye, Alan D. [3 ]
Varrassi, Giustino [5 ]
机构
[1] Louisiana State Univ Hlth Sci Ctr, Sch Med, Shreveport, LA USA
[2] Med Univ South Carolina, Sch Med, Charleston, SC USA
[3] Louisiana State Univ Hlth Sci Ctr, Dept Anesthesiol, Shreveport, LA 70112 USA
[4] Med Univ Silesia, Dept Internal Med Emergency Med, Katowice, Poland
[5] Paolo Procacci Fdn, Dept Pain Med, Rome, Italy
关键词
ige; clinical trials; immunotherapy; peanut allergy; palforzia; ORAL IMMUNOTHERAPY; EFFICACY; CHILDREN; SAFETY;
D O I
10.7759/cureus.50485
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
With Palforzia appearing as the first oral immunotherapy for patients with peanut allergy, the present investigation aims to summarize recent clinical trials, the mechanism of dosing, and the real-world usage of this novel therapy. Palforzia offers a new avenue for treating the human allergic response in previous immune modulation refractory patients or patients who have undergone immune environment sensitivity testing, which allows for more specialized treatment. Current studies are focusing on certain age groups that have been shown to be more receptive to treatment. Further, studies are tailoring oral immunotherapy treatment alongside other immune modulators to elicit greater targeted immune tolerance. With an increasing prevalence of patient allergies, many questions remain surrounding the optimization of therapies in reaching therapeutic goals. Overall, Palforzia offers a hopeful treatment for peanut-allergic patients to attenuate their immune response while furthering research in related therapies.
引用
收藏
页数:5
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