An orally available small molecule inhibitor for synthetic lethal targeting of MYC expressing tumors

被引：0
|
作者：
Shi, Qiong
Zhang, Ting
Kalashova, Julia
Li, Jinhua
Yang, Chenglu
Li, Hongmei
Zhou, Xiaohu
Long, Yan
Abuliezi, Yidan Xia
Lv, Gang
Yu, Duo
Zhang, Shenqiu
Zhang, Jing
Allen, Thaddeus D.
Liu, Hong
Yang, Dun
机构：
来源：
MOLECULAR CANCER THERAPEUTICS | 2023年 / 22卷 / 12期
关键词：
D O I：
10.1158/1535-7163.TARG-23-LB_C10
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
LB_C10
引用
收藏
页数：2
相关论文
共 50 条
  • [21] An orally available, small-molecule interferon inhibits viral replication
    Hideyuki Konishi
    Koichi Okamoto
    Yusuke Ohmori
    Hitoshi Yoshino
    Hiroshi Ohmori
    Motooki Ashihara
    Yuichi Hirata
    Atsunori Ohta
    Hiroshi Sakamoto
    Natsuko Hada
    Asao Katsume
    Michinori Kohara
    Kazumi Morikawa
    Takuo Tsukuda
    Nobuo Shimma
    Graham R. Foster
    William Alazawi
    Yuko Aoki
    Mikio Arisawa
    Masayuki Sudoh
    Scientific Reports, 2
  • [22] Potent antitumor activity of a novel and orally available small -molecule antagonist targeting the CD47/SIRPα pathway
    Sasikumar, Pottayil G.
    Gundala, Chennakrishnareddy
    Balasubramanian, Wesley R.
    Naremaddepalli, Sudarshan S.
    Bhumireddy, Archana
    Patil, Sandeep S.
    Dhudashiya, Amit A.
    Rayavarapu, Vijaysai
    Lakshminarasimhan, Anirudha
    Samiulla, Dodheri S.
    Aithal, Kiran
    Daginakatte, Girish
    Ramachandra, Murali
    MOLECULAR CANCER THERAPEUTICS, 2018, 17 (01)
  • [23] Preclinical pharmacokinetic characterizations and human pharmacokinetic prediction of AMG 900, an orally available small molecule inhibitor of aurora kinases
    Huang, Liyue
    Be, Xuhai
    Berry, Loren
    Pan, Wei-Jiang
    Zhao, Zhiyang
    Lin, Min-Hwa Jasmine
    CANCER RESEARCH, 2010, 70
  • [24] Antitumor activity of AMG 900, an orally available small molecule inhibitor of aurora kinases, alone and in combination with tubulin-targeting agents in human metastatic breast cancer
    Bush, Tammy L.
    HeIler, Scott
    Chung, Grace
    Guyot, Deborah
    Kendall, Richard
    Friberg, Greg
    Radinsky, Robert
    Payton, Marc
    CANCER RESEARCH, 2011, 71
  • [25] An orally available small molecule JMBI-001 elicits MYC-synthetic lethality and anti-tumor immunity by disabling MKLP2-mediated cellular processes
    Zhang, Ting
    Shi, Qiong
    Kalashova, Julia
    Liu, Xumei
    Zhou, Xiaohu
    Yang, Chenglu
    Long, Yan
    Li, Hongmei
    Li, Jinhua
    Lv, Gang
    Yu, Duo
    Jiang, Xuejiao
    Zhang, Shenqiu
    Zhang, Jing
    Liu, Hong
    Yang, Dun
    CANCER RESEARCH, 2024, 84 (06)
  • [26] A novel orally available small molecule that inhibits hepatitis B virus expression
    Mueller, Henrik
    Wildum, Steffen
    Luangsay, Souphalone
    Walther, Johanna
    Lopez, Anais
    Tropberger, Philipp
    Ottaviani, Giorgio
    Lu, Wenzhe
    Parrott, Neil John
    Zhang, Jitao David
    Schmucki, Roland
    Racek, Tomas
    Hoflack, Jean-Christophe
    Kueng, Erich
    Point, Floriane
    Zhou, Xue
    Steiner, Guido
    Luetgehetmann, Marc
    Rapp, Gianna
    Volz, Tassilo
    Dandri, Maura
    Yang, Song
    Young, John A. T.
    Javanbakht, Hassan
    JOURNAL OF HEPATOLOGY, 2018, 68 (03) : 412 - 420
  • [27] Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway
    Wang, Y
    Engels, IH
    Knee, DA
    Nasoff, M
    Deveraux, QL
    Quon, KC
    CANCER CELL, 2004, 5 (05) : 501 - 512
  • [28] Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma
    Liu, Rui-Ming
    Eldridge, Stephanie
    Watanabe, Nobuo
    Deshane, Jessy
    Kuo, Hui-Chien
    Jiang, Chunsun
    Wang, Yong
    Liu, Gang
    Schwiebert, Lisa
    Miyata, Toshio
    Thannickal, Victor J.
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2016, 310 (04) : 1328 - 1336
  • [29] Bone Anabolic Effects of a Novel Orally-Available Small Molecule SIK2/SIK3 Inhibitor
    Tang, Cheng-Chia
    Verma, Shiv
    De Vos, Steve
    Amantini, David
    Clement-Lacroix, Philippe
    Desroy, Nicolas
    Speziale, Antonio
    Brooks, Daniel
    Bouxsein, Mary
    Martins, Janaina Da Silva
    Zhao, Yingshe
    Kronenberg, Henry
    Wein, Marc
    ARTHRITIS & RHEUMATOLOGY, 2021, 73 : 922 - 924
  • [30] Bone Anabolic Effects of a Novel Orally-Available Small Molecule SIK2/ SIK3 Inhibitor
    Tang, Cheng-Chia
    Verma, Shiv
    De Vos, Steve
    Amantini, David
    Clement-Lacroix, Philippe
    Desroy, Nicolas
    Speziale, Antonio
    Brooks, Daniel J.
    Bouxsein, Mary L.
    Zhao, Yingshe
    Kronenberg, Henry M.
    Wein, Marc N.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2023, 38 : 48 - 49
12345