Dual wavelengths inverse Spatially Offset Raman Spectroscopy for bone characterization

被引：0

作者：

Ma, Hui ^{[1
,2
]}

Sekar, Sanathana Konugolu Venkata ^{[1
]}

Lanka, Pranav ^{[1
]}

O'Flynn, Carrie ^{[3
]}

Henn, Patrick ^{[3
]}

Andersson-Engels, Stefan ^{[1
,2
]}

Gautam, Rekha ^{[1
]}

机构：

[1] Tyndall Natl Inst, Lee Maltings Complex, Dyke Parade, Cork T12R5CP, Ireland

[2] Univ Coll Cork, Dept Phys, Coll Rd, Cork T12 K8AF, Ireland

[3] Univ Coll Cork, ASSERT Ctr, Coll Rd, Cork T12 K8AF, Ireland

来源：

ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC AND SURGICAL GUIDANCE SYSTEMS XXI | 2023年 / 12368卷

关键词：

Osteoporosis; Raman; SORS; BMD; Hydration;

D O I：

10.1117/12.2650089

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Osteoporosis is a disease that weakens bones increasing the possibility of bone fracture. The gold standard to diagnose osteoporosis is measuring bone mineral density (BMD). Since BMD only partly determines the strength of the bone, more information on chemical composition and microstructure is needed. Here, we implemented a novel dual-wavelength inverse Spatially Offset Raman Spectroscopy (SORS) to characterize tissue chemical composition covering both the fingerprint and high-wavenumber regions. This system provides a greater probing depth keeping the spectrometer setting constant. The results from hydroxyapatite (HA) and water phantom demonstrate the potential of the Raman system to assess bone mineral and matrix quality in-vivo.

引用

页数：4

共 50 条

[21] Passive signal enhancement in spatially offset Raman spectroscopy
Eliasson, Charlotte
Matousek, Pavel
JOURNAL OF RAMAN SPECTROSCOPY, 2008, 39 (05) : 633 - 637
[22] Spatially offset Raman spectroscopy of layered soft tissues
Keller, Matthew D.
Majumder, Shovan K.
Mahadevan-Lansen, Anita
OPTICS LETTERS, 2009, 34 (07) : 926 - 928
[23] Applications of Spatially Offset Raman Spectroscopy for Defense and Security
Guicheteau, Jason
Hopkins, Rebecca
CHEMICAL, BIOLOGICAL, RADIOLOGICAL, NUCLEAR, AND EXPLOSIVES (CBRNE) SENSING XVII, 2016, 9824
[24] Spatially Offset Raman Spectroscopy (SORS) for Liquid Screening
Loeffen, Paul W.
Maskall, Guy
Bonthron, Stuart
Bloomfield, Matthew
Tombling, Craig
Matousek, Pavel
OPTICS AND PHOTONICS FOR COUNTERTERRORISM AND CRIME FIGHTING VII OPTICAL MATERIALS IN DEFENCE SYSTEMS TECHNOLOGY VIII AND QUANTUM-PHYSICS-BASED INFORMATION SECURITY, 2011, 8189
[25] Hyperspectral spatially offset Raman spectroscopy in a microfluidic channel
Matthiae, Moritz
Kristensen, Anders
OPTICS EXPRESS, 2019, 27 (03) : 3782 - 3790
[26] Spatially Offset Raman Spectroscopy-How Deep?
Mosca, Sara
Dey, Priyanka
Salimi, Marzieh
Gardner, Benjamin
Palombo, Francesca
Stone, Nick
Matousek, Pavel
ANALYTICAL CHEMISTRY, 2021, 93 (17) : 6755 - 6762
[27] Sensitivity of the amide I band to matrix manipulation in bone: a Raman micro-spectroscopy and spatially offset Raman spectroscopy study
Ahmed, Rafay
Unal, Mustafa
Gautam, Rekha
Uppuganti, Sasidhar
Derasari, Shrey
Mahadevan-Jansen, Anita
Nyman, Jeffry S.
ANALYST, 2023, 148 (19) : 4799 - 4809
[28] Defocused Spatially Offset Raman Spectroscopy in Media of Different Optical Properties for Biomedical Applications Using a Commercial Spatially Offset Raman Spectroscopy Device
Vardaki, Martha Z.
Devine, Dana, V
Serrano, Katherine
Simantiris, Nikolaos
Blades, Michael W.
Piret, Jarnes M.
Turner, Robin F. B.
APPLIED SPECTROSCOPY, 2020, 74 (02) : 223 - 232
[29] Determination of Spatially Offset Raman Spectroscopy Geometry Suitable for Human Hand Bone Quality Assessment
Massie, Christine
Chen, Keren
Awad, Hani A.
Berger, Andrew J.
TRANSLATIONAL BIOPHOTONICS: DIAGNOSTICS AND THERAPEUTICS, 2021, 11919
[30] Application of portable Raman spectroscopy and benchtop spatially offset Raman spectroscopy to interrogate concealed biomaterials
Hargreaves, Michael D.
Macleod, Neil A.
Brewster, Victoria L.
Munshi, Tasnim
Edwards, Howell G. M.
Matousek, Pavel
JOURNAL OF RAMAN SPECTROSCOPY, 2009, 40 (12) : 1875 - 1880

← 1 2 3 4 5 →