A review of transgenerational and multigenerational toxicology in the in vivo model animal Caenorhabditis elegans

被引：43

作者：

Zhao, Yunli ^{[1
,2
]}

Chen, Jingya ^{[2
]}

Wang, Rui ^{[2
]}

Pu, Xiaoxiao ^{[2
]}

Wang, Dayong ^{[1
]}

机构：

[1] Southeast Univ, Med Sch, Nanjing 210009, Peoples R China

[2] Bengbu Med Coll, Sch Publ Hlth, Bengbu, Peoples R China

来源：

JOURNAL OF APPLIED TOXICOLOGY | 2023年 / 43卷 / 01期

基金：

中国博士后科学基金;

关键词：

Caenorhabditis elegans; environmental pollutants; in vivo model; multigenerational toxicity; transgenerational toxicity; TRANSFERABLE PROPERTIES; GOLD NANOPARTICLES; PARTICULATE MATTER; BEHAVIORAL DEFECTS; EPIGENETIC MEMORY; MATERNAL TRANSFER; STRESS-RESPONSE; SMALL RNAS; EXPOSURE; TOXICITY;

D O I：

10.1002/jat.4360

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

A large number of pollutants existing in the environment can last for a long time, and their potential toxic effects can transfer from parents to their offspring. Thus, it is necessary to investigate the toxicity of environmental pollutants across multigenerations and the underlying mechanisms in organisms. Due to its short life cycle and sensitivity to environmental exposures, Caenorhabditis elegans is an important animal model for toxicity assessment of environmental pollutants across multigenerations. In this review, we introduced the transgenerational and multigenerational toxicity caused by various environmental pollutants in C. elegans. Moreover, we discussed the underlying mechanisms for the observed transgenerational and multigenerational toxicity of environmental contaminants in C. elegans.

引用

页码：122 / 145

页数：24

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