Recent Advancements in Gremlin-1: Breast cancer

被引：1

作者：

Inam, Nimrah ^{[1
]}

Hameed, Ayesha ^{[2
]}

Vohra, Lubna ^{[3
]}

Zeeshan, Sana ^{[3
]}

机构：

[1] Aga Khan Univ Hosp, Dept Paediat, Karachi, Pakistan

[2] Jinnah Med & Dent Coll, Karachi, Pakistan

[3] Aga Khan Univ Hosp, Dept Breast Surg, Karachi, Pakistan

来源：

JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION | 2023年 / 73卷 / 02期

关键词：

Bone Morphogenetic; Carcinogenesis; Organogenesis; Colorectal Neoplasms; breast cancers; stem cells; TARGETED THERAPIES; CELLS; METASTASIS; GROWTH;

D O I：

10.47391/JPMA.AKUS-25

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

One of the bone's morphogenic protein (BMP) antagonists, Gremlin-1 or GREM-1, can bind directly to BMPs. GREM-1 can act in either BMP-dependent or independent pathways, according to research. It reinforces organogenesis, tissue differentiation, and organ fibrosis. Recent research from numerous studies has demonstrated the significance of GREM-1 in the initiation, progression, and even metastasis of different cancers, including breast, cervical, gastric, and colorectal cancers. This review highlights the function of GREM-1 in the development of breast cancer and its effect on the cellular procedures and signalling pathways involved in carcinogenesis.

引用

页码：S155 / S159

页数：5

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