Mechanical and Antibacterial Properties of Bone Cement Composites Containing Silver Nanoparticles Compounded with Various Types of Chitosan

被引:0
|
作者
Li, Zhuoyang [1 ,2 ]
Yang, Xin [1 ]
Cao, Yongping [1 ]
Meng, Zhichao [1 ]
Liu, Heng [1 ]
Wang, Rui [1 ]
Wu, Hao [1 ]
机构
[1] Peking Univ First Hosp, Dept Orthoped, Beijing 100034, Peoples R China
[2] Zhejiang Univ, Dept Orthoped, Sch Med, Affiliated Hosp 1, Hangzhou 310000, Zhejiang, Peoples R China
关键词
Silver Nanoparticles; Chitosan; Compressive Strength; Bending Strength; Antibacterial Properties;
D O I
10.1166/jbt.2023.3323
中图分类号
Q813 [细胞工程];
学科分类号
摘要
To analyze the mechanical and antibacterial properties of bone cement composites that contain silver nanoparticles (AgNPs) compounded with chitosan (CS) and carboxymethyl chitosan (CMCS). An oxidation-reduction reaction was performed under sonic oscillation to prepare ten percent wt% AgNPs, CS-AgNPs and CMCS-AgNPs, which were subsequently mixed with polymethyl methacrylate (PMMA). The compressive and bending strengths of these nanoparticles were measured before and after the samples were soaked in simulated body fluid (SBF). The Kirby-Bauer (K-B) method and flask oscillation method were used to evaluate the antibacterial effects of the composites. The compressive and bending strengths of the AgNP, CS-AgNP, and CMCS-AgNP groups were significantly improved (P < 0.001). After the AgNP, CS-AgNP, and CMCS-AgNP groups were soaked in SBF, their bending strengths were significantly higher than that of the control group (P < 0.001). The K-B test showed that only the 5 wt% and 10 wt% CMCS-AgNP groups exhibited bacteriostatic rings for Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Flask oscillation analyses revealed that the 5 wt% and 10 wt% CMCS-AgNP exhibited good bacteriostatic activity against S. aureus, but good activity against MRSA was only observed for the 10 wt% CMCS-AgNP group. We developed CS/CMCS-AgNP bone cement composites that show good mechanical properties and antibacterial activity.
引用
收藏
页码:914 / 924
页数:11
相关论文
共 50 条
  • [31] Preparation and characterization of chitosan-poloxamer-based antibacterial hydrogel containing silver nanoparticles
    Li, Daheng
    Yu, Xuefei
    Hu, Yunrui
    Xi, Tingfei
    Chen, Jia
    Zhang, Zhixiong
    Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering, 2016, 33 (06): : 1124 - 1132
  • [32] Gamma Radiation Synthesis of Silver Nanoparticles/Chitosan Composites with Antimicrobial Properties
    Lungulescu, Eduard-Marius
    Setnescu, Radu
    Nicula, Nicoleta-Oana
    Ion, Ioana
    Marinescu, Virgil
    MATERIALE PLASTICE, 2020, 57 (04) : 88 - 95
  • [33] Cellulose Whiskers Influence the Morphology and Antibacterial Properties of Silver Nanoparticles Composites
    Teodoro, Kelcilene B. R.
    Sanfelice, Rafaela C.
    Mattoso, Luiz. H. C.
    Correa, Daniel S.
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2018, 18 (07) : 4876 - 4883
  • [34] Mechanical, elution, and antibacterial properties of simplex bone cement loaded with vancomycin
    Kim, Sunjung
    Bishop, Aaron R.
    Squire, Matthew W.
    Rose, Warren E.
    Ploeg, Heidi-Lynn
    JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2020, 103
  • [35] Silver Nanoparticles Stabilized Using Chitosan Films: Preparation, Properties and Antibacterial Activity
    Kolarova, K.
    Vosmanska, V.
    Rimpelova, S.
    Ulbrich, P.
    Svorcik, V.
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2015, 15 (12) : 10120 - 10126
  • [36] Fabrication of New Chitosan-Based Composite Sponge Containing Silver Nanoparticles and Its Antibacterial Properties for Wound Dressing
    Li, Donghong
    Diao, Junlin
    Zhang, Jiaotao
    Liu, Jianchang
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2011, 11 (06) : 4733 - 4738
  • [37] Antibacterial Properties of Novel Bacterial Cellulose Nanofiber Containing Silver Nanoparticles
    Yang Jiazhi
    Liu Xiaoli
    Huang Liyong
    Sun Dongping
    CHINESE JOURNAL OF CHEMICAL ENGINEERING, 2013, 21 (12) : 1419 - 1424
  • [38] Properties of chitosan/magnetite nanoparticles composites for efficient dye adsorption and antibacterial agent
    Haldorai, Yuvaraj
    Kharismadewi, Dian
    Tuma, Dirk
    Shim, Jae-Jin
    KOREAN JOURNAL OF CHEMICAL ENGINEERING, 2015, 32 (08) : 1688 - 1693
  • [39] Properties of chitosan/magnetite nanoparticles composites for efficient dye adsorption and antibacterial agent
    Yuvaraj Haldorai
    Dian Kharismadewi
    Dirk Tuma
    Jae-Jin Shim
    Korean Journal of Chemical Engineering, 2015, 32 : 1688 - 1693
  • [40] Preparation of a novel antibacterial chitosan-poly(ethylene glycol) cryogel/silver nanoparticles composites
    Zou, Xueqing
    Deng, Pengpeng
    Zhou, Changjiang
    Hou, Yulin
    Chen, Rongsheng
    Liang, Feng
    Liao, Liqiong
    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2017, 28 (13) : 1324 - 1337