Severe intestinal barrier damage in HIV-infected immunological non-responders

被引：6

作者：

Guo, Xiao-Yan ^{[1
,2
]}

Guo, Yun-Tian ^{[2
,3
]}

Wang, Ze-Rui ^{[4
]}

Jiao, Yan-Mei ^{[2
]}

Hu, Yue ^{[5
]}

Fan, Li-Na ^{[5
]}

Cheng, Rui-Qin ^{[6
]}

Qu, Meng-Meng ^{[2
]}

Zhang, Chao ^{[2
]}

Song, Jin-Wen ^{[2
]}

Xu, Ruo-Nan ^{[2
]}

Fan, Xing ^{[2
]}

Xu, Wen ^{[2
]}

Zhang, Ji-Yuan ^{[2
]}

Bai, Bing-Ke ^{[2
]}

Linghu, En-Qiang ^{[4
]}

Chen, Yao-Kai ^{[7
]}

Ma, Ping ^{[5
]}

Wang, Fu-Sheng ^{[1
,2
,3
]}

机构：

[1] Capital Med Univ, Beijing Ditan Hosp, Beijing, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Infect Dis, Dept Infect Dis, Med Ctr 5, Beijing, Peoples R China

[3] Southern Med Univ, Sch Clin Med 2, Guangzhou, Peoples R China

[4] Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol, Med Ctr 1, Beijing, Peoples R China

[5] Tianjin Second Peoples Hosp, Dept Infect Dis, Tianjin, Peoples R China

[6] Tianjin Bright Eye Hosp, Tianjin, Peoples R China

[7] Chongqing Publ Hlth Med Ctr, Dept Infect Dis, Chongqing, Peoples R China

来源：

HELIYON | 2023年 / 9卷 / 10期

基金：

中国国家自然科学基金;

关键词：

HIV; Intestinal damage; Immunological responders; Immunological non-responders; NECROSIS-FACTOR-ALPHA; IMMUNODEFICIENCY-VIRUS-INFECTION; T-CELL DEPLETION; EPITHELIAL BARRIER; ANTIRETROVIRAL THERAPY; IMMUNE ACTIVATION; MICROBIAL TRANSLOCATION; TNF-ALPHA; TYPE-1; INFECTION; LYMPHOID-TISSUE;

D O I：

10.1016/j.heliyon.2023.e20790

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The intestinal epithelial barrier plays an important role during human immunodeficiency virus (HIV) disease progression. However, the extent to which the intestinal epithelial barrier is damaged in immunological non-responders (INRs) and immunological responders (IRs) is largely unknown. In this study, we investigated and compared the levels of intestinal gland damage and related molecules, including the tight junction protein claudin-1, apoptosis marker caspase-3, HIV DNA, CD4(+) T cell count, and inflammation marker tumor necrosis factor-alpha (TNF-alpha) among the IRs (n = 10), INRs (n = 8), and healthy controls (HCs, n = 7). Intestinal damage was not completely restored in both INRs and IRs and was more serious in INRs than that in IRs. Moreover, intestinal damage was positively correlated with HIV DNA levels and negatively correlated with CD4(+) T cell counts. These results provide insight into understanding the characteristics of intestinal epithelial barrier damage between IRs and INRs.

引用

页数：11

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