Targeting CREB-Binding Protein (CREBBP) Overcomes Resistance to Azacitidine and Venetoclax Therapy in Acute Myeloid Leukemia (AML)

被引：1
|
作者：
LeBlanc, Francis [1 ]
Bennett, Josh [2 ]
Choi, Kwangmin [3 ]
Starczynowski, Daniel T. [4 ]
机构：
[1] Cincinnati Childrens Hosp Med Ctr, Canc & Blood Dis Inst, Cincinnati, OH USA
[2] Univ Cincinnati, Coll Med, Cincinnati, OH USA
[3] Cincinnati Childrens Hosp Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH USA
[4] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH USA
来源：
BLOOD | 2023年 / 142卷
关键词：
D O I：
10.1182/blood-2023-187063
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：3
相关论文
共 50 条
  • [41] Targeting of the leukemia microenvironment by c(RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds
    Shen, Zhao-Hua
    Zeng, Dong-Feng
    Wang, Xiao-Yan
    Ma, Ying-Ying
    Zhang, Xi
    Kong, Pei-Yan
    ONCOLOGY LETTERS, 2016, 12 (05) : 3278 - 3284
  • [42] High Throughput Pre-Clinical Models to Determine a Synergistic Molar Ratio of 5-Azacitidine to Venetoclax and Uncover Resistance Mechanisms to 5-Azacitidine and Venetoclax Combination Therapy in Acute Myeloid Leukemia
    Sarangdhar, Mithun Milind
    O'Brien, Eric
    VanCauwenbergh, Brett
    Alexander, Jackson
    Theile, Caroline
    Basu, Mitali
    Sarangdhar, Mayur
    Seibel, William
    Perentesis, John P.
    BLOOD, 2022, 140 : 10693 - 10694
  • [43] Breast cancer resistance protein (BCRP) expression in acute myeloid leukemia (AML).
    Suvannasankha, A
    Minderman, H
    O'Loughlin, KL
    Blumenson, LE
    Scheper, RJ
    Baer, MR
    BLOOD, 2001, 98 (11) : 307A - 307A
  • [44] Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia
    Wang, Eric
    Lu, Sydney X.
    Pastore, Alessandro
    Chen, Xufeng
    Imig, Jochen
    Lee, Stanley Chun-Wei
    Hockemeyer, Kathryn
    Ghebrechristos, Yohana E.
    Yoshimi, Akihide
    Inoue, Daichi
    Ki, Michelle
    Cho, Hana
    Bitner, Lillian
    Kloetgen, Andreas
    Lin, Kuan-Ting
    Uehara, Taisuke
    Owa, Takashi
    Tibes, Raoul
    Krainer, Adrian R.
    Abdel-Wahab, Omar
    Aifantis, Iannis
    CANCER CELL, 2019, 35 (03) : 369 - +
  • [45] Outcomes and Survival in Newly Diagnosed, Older, Acute Myeloid Leukemia Patients from the Beat AML Master Trial in the Venetoclax/Azacitidine Age
    Borate, Uma
    Huang, Ying
    Li Welkie, Rina
    Swords, Ronan T.
    Traer, Elie
    Stein, Eytan M.
    Lin, Tara L.
    Madanat, Yazan F.
    Patel, Prapti A.
    Collins, Robert H.
    Baer, Maria R.
    Duong, Vu H.
    Blum, William
    Arellano, Martha L.
    Stock, Wendy
    Odenike, Olatoyosi
    Redner, Robert L.
    Kovacsovics, Tibor J.
    Deininger, Michael W.
    Zeidner, Joshua F.
    Olin, Rebecca
    Smith, Catherine C.
    Foran, James M.
    Schiller, Gary J.
    Curran, Emily K.
    Koenig, Kristin L.
    Heerema, Nyla A.
    Chen, Timothy
    Martycz, Molly
    Stefanos, Mona
    Marcus, Sonja Gullen
    Druker, Brian J.
    Levine, Ross L.
    Burd, Amy
    Rossenber, Leohard
    Yocum, Ashley Owen
    Mims, Alice
    Byrd, John C.
    BLOOD, 2024, 144 : 4324 - 4326
  • [46] Implementing RNAi Therapy Targeting FLT3 in Acute Myeloid Leukemia (AML)
    Ansari, Aysha
    Bahadur, Remant K. C.
    Nasrullah, Mohammad
    Sundaram, Daniel N. M.
    Burbano, Luis Morales
    Brandwein, Joseph
    Jiang, Xiaoyan
    Uludag, Hasan
    BLOOD, 2022, 140 : 7791 - 7792
  • [47] Targeting metabolic vulnerabilities to overcome resistance to therapy in acute myeloid leukemia
    Sharma, Priyanka
    Borthakur, Gautam
    CANCER DRUG RESISTANCE, 2023, 6 (03) : 567 - 589
  • [48] Successful use of Palbociclib combined with Venetoclax and Azacitidine in an adult with refractory/relapsed therapy-related acute myeloid leukemia
    Qu, Wenqiang
    Lu, Jialing
    Ji, Yujie
    He, Zhewei
    Hou, Mengjia
    Li, Dongyang
    Yang, Yan
    Liu, Dan
    Chen, Suning
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2024, 94 (04) : 635 - 639
  • [49] VENETOCLAX PLUS AZACITIDINE AS FIRST LINE THERAPY IN PATIENTS AFFECTED BY ACUTE MYELOID LEUKEMIA: A REAL-LIFE EXPERIENCE
    Lico, A.
    Greco, G.
    Perbellini, O.
    Facchinelli, D.
    Riva, M.
    Miggiano, M. C.
    Pomponi, F.
    Schiavotto, C.
    Scomazzon, E.
    Di Bona, E.
    Ruggeri, M.
    HAEMATOLOGICA, 2021, 106 (10) : 134 - 134
  • [50] Design of the VIALE-M phase III trial of venetoclax and oral azacitidine maintenance therapy in acute myeloid leukemia
    Ivanov, Vladimir
    Yeh, Su-Peng
    Mayer, Jiri
    Saini, Lalit
    Unal, Ali
    Boyiadzis, Michael
    Hoffman, David M.
    Kang, Kingston
    Addo, Sadiya N.
    Mendes, Wellington L.
    Fathi, Amir T.
    FUTURE ONCOLOGY, 2022, 18 (26) : 2879 - 2889
12345