Targeting CREB-Binding Protein (CREBBP) Overcomes Resistance to Azacitidine and Venetoclax Therapy in Acute Myeloid Leukemia (AML)

被引:1
|
作者
LeBlanc, Francis [1 ]
Bennett, Josh [2 ]
Choi, Kwangmin [3 ]
Starczynowski, Daniel T. [4 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Canc & Blood Dis Inst, Cincinnati, OH USA
[2] Univ Cincinnati, Coll Med, Cincinnati, OH USA
[3] Cincinnati Childrens Hosp Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH USA
[4] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH USA
关键词
D O I
10.1182/blood-2023-187063
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:3
相关论文
共 50 条
  • [1] Targeting Mitochondrial Translation Overcomes Venetoclax Resistance in Acute Myeloid Leukemia (AML) through Activation of the Integrated Stress Response
    Sharon, David
    Cathelin, Severine
    Subedi, Amit
    Williams, Ryan
    Benicio, Mariana
    Ketela, Troy
    Chan, Steven M.
    BLOOD, 2017, 130
  • [2] Venetoclax Overcomes Sorafenib Resistance in Acute Myeloid Leukemia by Targeting BCL2
    Xu, Xi
    Ma, Weiwei
    Qiu, Guo
    Xuan, Li
    He, Chong
    Zhang, Tian
    Wang, Jian
    Liu, Qifa
    BIOLOGY-BASEL, 2023, 12 (10):
  • [3] Boanmycin induces apoptosis and overcomes venetoclax resistance in acute myeloid leukemia
    Wang, Jin-Xing
    Zhang, Peng-Wei
    Yuan, Luo-Wei
    Jiang, Jian
    Cheng, Xiao-Hui
    Li, Ju-Heng
    Tang, Mei-Qin
    Fan, Jiao-Yang
    Zhu, Wei
    Lei, Yong
    Tian, Fa-Qing
    ONCOLOGIE, 2024, 26 (05) : 743 - 752
  • [4] Durable Response with Venetoclax in Combination with Decitabine or Azacitidine in Elderly Patients with Acute Myeloid Leukemia (AML)
    DiNardo, Courtney D.
    Pratz, Keith
    Potluri, Jalaja
    Pullarkat, Vinod
    Jonas, Brian A.
    Wei, Andrew H.
    Becker, Pamela S.
    Frankfurt, Olga
    Xu, Tu
    Hong, Wan-Jen
    Chyla, Brenda
    Pollyea, Daniel A.
    Letai, Anthony
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2018, 18 : S201 - S201
  • [5] Olverembatinib (HQP1351) in Combination with Lisaftoclax Overcomes Venetoclax Resistance in Preclinical Model of Acute Myeloid Leukemia (AML)
    Xiong, Yan
    Liang, Zhiyan
    Min, Ping
    Wu, Bingxing
    Yu, Huidan
    Yang, Dajun
    Zhai, Yifan
    BLOOD, 2024, 144 : 5777 - 5778
  • [6] Venetoclax and azacitidine therapy in acute myeloid leukemia patients with severe renal impairment
    Naka, Ryosuke
    Kondo, Tadakazu
    Nishikubo, Masashi
    Muranushi, Hiroyuki
    Ueda, Yasunori
    Oka, Tomomi
    Wada, Fumiya
    Kanda, Junya
    Yamamoto, Shohei
    Watanabe, Mitsumasa
    Okada, Shinri
    Imada, Kazunori
    Nakabo, Yukiharu
    Mizutani, Yu
    Nannya, Yasuhito
    Ogawa, Seishi
    Ishikawa, Takayuki
    AMERICAN JOURNAL OF HEMATOLOGY, 2023, 98 (09) : E251 - E254
  • [7] Homoharringtonine Overcomes Drug Resistance and Synergises with Venetoclax in Acute Myeloid Leukemia Via Inhibiting Protein Synthesis
    Kwok, Tsz Ho
    Wong, Kelvin King Wai
    Lam, Wing
    Dang, Chee Chean
    Zeng, Xiaoyuan
    Leung, Wing Yan
    Ng, Timothy Chi Chun
    Leung, Anskar
    Man, Cheuk Him
    BLOOD, 2022, 140 : 11540 - 11540
  • [8] Acquired resistance to venetoclax plus azacitidine in acute myeloid leukemia: In vitro models and mechanisms
    Carter, Jenna L.
    Su, Yongwei
    Qiao, Xinan
    Zhao, Jianlei
    Wang, Guan
    Howard, Mackenzie
    Edwards, Holly
    Bao, Xun
    Li, Jing
    Huettemann, Maik
    Yang, Jay
    Taub, Jeffrey W.
    Ge, Yubin
    BIOCHEMICAL PHARMACOLOGY, 2023, 216
  • [9] Early response to therapy with 5-azacitidine and venetoclax in three transplant-ineligible patients with acute myeloid leukemia (AML)
    Steiner, L.
    Jawhar, M.
    Fabarius, A.
    Nowak, D.
    Hofmann, W. - K.
    Metzgeroth, G.
    ONCOLOGY RESEARCH AND TREATMENT, 2022, 45 (SUPPL 2) : 203 - 203
  • [10] Phase 2 study of azacitidine (AZA) and venetoclax (VEN) as maintenance therapy for acute myeloid leukemia (AML) patients in remission.
    Bazinet, Alexandre
    Kantarjian, Hagop M.
    Borthakur, Gautam
    Yilmaz, Musa
    Bose, Prithviraj
    Jabbour, Elias
    Valero, Yesid Alvarado
    Chien, Kelly Sharon
    Pemmaraju, Naveen
    Takahashi, Koichi
    Short, Nicholas James
    Daver, Naval Guastad
    Issa, Ghayas C.
    Jain, Nitin
    Bull-Linderman, Debra
    Dinardo, Courtney Denton
    Garcia-Manero, Guillermo
    Sasaki, Koji
    Ravandi, Farhad
    Kadia, Tapan M.
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16) : E19018 - E19018