Altered cortical myelin in the salience and default mode networks in major depressive disorder patients: A surface-based analysis

Introduction: Evidence from previous genetic and post-mortem studies suggested that the myelination abnormality contributed to the pathogenesis of major attempted to detect the clusters with significant differences in cortical myelin content between MDD and HC groups. We correlated the cluster-wise averaged myelin Results: The MDD patients showed significantly lower cortical myelin content in the cluster involving the left insula, orbitofrontal cortex, superior temporal cortex, transverse temporal gyrus, inferior frontal cortex, superior frontal gyrus, anterior cingulate cortex, precentral cortex, and postcentral cortex. The correlation analysis Conclusion: The MDD patients showed lower cortical myelin content in regions of the default mode network regions and salience network than healthy controls.