Morphologies, mechanical and in vitro behaviors of DLP-based 3D printed HA scaffolds with different structural configurations

被引：11
|
作者：
Liu, Ke [1 ,2 ]
Zhou, Qing [3 ]
Zhang, Xueqin [3 ]
Ma, Lili [1 ]
Xu, Baohua [1 ]
He, Rujie [3 ]
机构：
[1] China Japan Friendship Hosp, Ctr Stomatol, Beijing 100029, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Grad Sch Peking Union Med Coll, Beijing 100029, Peoples R China
[3] Beijing Inst Technol, Beijing Key Lab Lightweight Multifunct Composite M, Beijing 100081, Peoples R China
来源：
RSC ADVANCES | 2023年 / 13卷 / 30期
基金：
中国国家自然科学基金;
关键词：
GROWTH-FACTOR; BONE; DESIGN; BIOMATERIALS; ARCHITECTURE; OSTEOPONTIN; PROTEIN; VEGF;
D O I：
10.1039/d3ra03080f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the field of bone engineering, porous ceramic scaffolds are in great demand for repairing bone defects. In this study, hydroxyapatite (HA) ceramic scaffolds with three different structural configurations, including the body-centered cubic (BCC), the face-centered cubic (FCC), and the triply periodic minimal surface (TPMS), were fabricated through digital light processing (DLP) based 3D printing technologies. The effects of the structural configurations on the morphologies and mechanical properties of the DLP-based 3D printed HA scaffolds were characterized. Furthermore, in vitro evaluations, including in vitro cytocompatibility, bone alkaline phosphatase (ALP) activity assay, and protein expression, were conducted to assess HA scaffold behavior. Finally, we evaluated the effects of structural configurations from these aspects and selected the most suitable structure of HA scaffold for bone repair.
引用
收藏
页码：20830 / 20838
页数：9
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