The Role of the WGR Domain in the Functions of PARP1 and PARP2

被引：0
|
作者：
Maluchenko, N. V. [1 ]
Korovina, A. N. [1 ]
Saulina, A. A. [1 ]
Studitsky, V. M. [1 ,2 ]
Feofanov, A. V. [1 ,3 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Biol, Moscow 119234, Russia
[2] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
[3] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia
来源：
MOLECULAR BIOLOGY | 2023年 / 57卷 / 05期
关键词：
PARP1; PARP2; WGR; inhibitors; DNA-DAMAGE; POLY(ADP-RIBOSE) POLYMERASE; ALLOSTERIC REGULATION; ACTIVATION; BREAKS; MAINTENANCE; MECHANISM; BINDING; SITES; CELLS;
D O I：
10.1134/S0026893323050114
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The PARP1 and PARP2 proteins are members of the poly(ADP-ribose) polymerase family involved in the regulation of DNA repair and replication, RNA processing, ribosome biogenesis, transcription, cell division, and cell death. PARP1 and PARP2 are promising targets for the development of anticancer drugs and can be used in the treatment of cardiovascular, neurodegenerative, and other disorders. The WGR domain has been shown to play a central role in the functioning of PARP1 and PARP2 proteins. This review considers the mechanisms of functioning of WGR domains in the PARP1 and PARP2 proteins, which have several similar and specialized properties. Understanding these processes is of great interest to fundamental science and can contribute to the development of more effective and selective inhibitors of PARP1 and PARP2.
引用
收藏
页码：802 / 810
页数：9
相关论文
共 50 条
  • [31] PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites
    Lin, Xiaohui
    Jiang, Wenxia
    Rudolph, Johannes
    Lee, Brian J.
    Luger, Karolin
    Zha, Shan
    NUCLEIC ACIDS RESEARCH, 2022, 50 (07) : 3958 - 3973
  • [32] The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context
    Kutuzov, M. M.
    Belousova, E. A.
    Kurgina, T. A.
    Ukraintsev, A. A.
    Vasil'eva, I. A.
    Khodyreva, S. N.
    Lavrik, O. I.
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [33] The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context
    M. M. Kutuzov
    E. A. Belousova
    T. A. Kurgina
    A. A. Ukraintsev
    I. A. Vasil’eva
    S. N. Khodyreva
    O. I. Lavrik
    Scientific Reports, 11
  • [34] PARP inhibition: PARP1 and beyond
    Rouleau, Michele
    Patel, Anand
    Hendzel, Michael J.
    Kaufmann, Scott H.
    Poirier, Guy G.
    NATURE REVIEWS CANCER, 2010, 10 (04) : 293 - 301
  • [35] PARP inhibition: PARP1 and beyond
    Michèle Rouleau
    Anand Patel
    Michael J. Hendzel
    Scott H. Kaufmann
    Guy G. Poirier
    Nature Reviews Cancer, 2010, 10 : 293 - 301
  • [36] PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs
    Wang, Luyao
    Liang, Chao
    Li, Fangfei
    Guan, Daogang
    Wu, Xiaoqiu
    Fu, Xuekun
    Lu, Aiping
    Zhang, Ge
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (10)
  • [37] Binding to WGR Domain by Salidroside Activates PARP1 and Protects Hematopoietic Stem Cells from Oxidative Stress
    Li, Xue
    Erden, Ozlem
    Li, Liang
    Ye, Qidong
    Wilson, Andrew
    Du, Wei
    ANTIOXIDANTS & REDOX SIGNALING, 2014, 20 (12) : 1853 - 1865
  • [38] Pleiotropic role of PARP1: an overview
    Vikas Kumar
    Anurag Kumar
    Khursheed Ul Islam Mir
    Vandana Yadav
    Shyam Singh Chauhan
    3 Biotech, 2022, 12
  • [39] Pleiotropic role of PARP1: an overview
    Kumar, Vikas
    Kumar, Anurag
    Mir, Khursheed Ul Islam
    Yadav, Vandana
    Chauhan, Shyam Singh
    3 BIOTECH, 2022, 12 (01)
  • [40] Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging
    Mahadevan, Jyothi
    Jha, Asmita
    Rudolph, Johannes
    Bowerman, Samuel
    Narducci, Domenic
    Hansen, Anders S.
    Luger, Karolin
    ISCIENCE, 2023, 26 (01)
12345