Therapeutic potential of dual CDK12 and 13 inhibition in colorectal cancer

被引:0
|
作者
Altunel, Erdem
Zokaasadi, Mohammad
Somarelli, Jason A.
McCall, Shannon J.
Gultawatvichai, Patan
Whalen, Giles Francis
Pitarresi, Jason
Hsu, David S.
机构
[1] UMass Chan Med Sch, Div Hematol Oncol, Dept Med, Worcester, MA USA
[2] Duke Univ, Div Med Oncol, Dept Med, Med Ctr, Durham, NC USA
[3] Duke Univ, Dept Pathol, Med Ctr, Durham, NC USA
[4] UMass Chan Med Sch, Div Surg Oncol, Dept Surg, Worcester, MA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
e15601
引用
收藏
页数:1
相关论文
共 50 条
  • [11] Dual inhibition of CDK12 and CDK13 uncovers actionable vulnerabilities in patient-derived ovarian cancer organoids
    Cesari, Eleonora
    Ciucci, Alessandra
    Pieraccioli, Marco
    Caggiano, Cinzia
    Nero, Camilla
    Bonvissuto, Davide
    Sillano, Francesca
    Buttarelli, Marianna
    Piermattei, Alessia
    Loverro, Matteo
    Camarda, Floriana
    Greco, Viviana
    De Bonis, Maria
    Minucci, Angelo
    Gallo, Daniela
    Urbani, Andrea
    Vizzielli, Giuseppe
    Scambia, Giovanni
    Sette, Claudio
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023, 42 (01)
  • [12] Dual inhibition of CDK12 and CDK13 uncovers actionable vulnerabilities in patient-derived ovarian cancer organoids
    Eleonora Cesari
    Alessandra Ciucci
    Marco Pieraccioli
    Cinzia Caggiano
    Camilla Nero
    Davide Bonvissuto
    Francesca Sillano
    Marianna Buttarelli
    Alessia Piermattei
    Matteo Loverro
    Floriana Camarda
    Viviana Greco
    Maria De Bonis
    Angelo Minucci
    Daniela Gallo
    Andrea Urbani
    Giuseppe Vizzielli
    Giovanni Scambia
    Claudio Sette
    Journal of Experimental & Clinical Cancer Research, 42
  • [13] Role and therapeutic potential of CDK12 in human cancers
    Chila, Rosaria
    Guffanti, Federica
    Damia, Giovanna
    CANCER TREATMENT REVIEWS, 2016, 50 : 83 - 88
  • [14] CDK12/13: A Promising New Therapeutic Target in ALL
    Dudkiewicz, Julia
    Garbicz, Filip
    Wlodarski, Pawel Krzysztof
    BLOOD, 2023, 142
  • [15] Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13
    Zeng, Mei
    Kwiatkowski, Nicholas P.
    Zhang, Tinghu
    Nabet, Behnam
    Xu, Mousheng
    Liang, Yanke
    Quan, Chunshan
    Wang, Jinhua
    Hao, Mingfeng
    Palakurthi, Sangeetha
    Zhou, Shan
    Zeng, Qing
    Kirschmeier, Paul T.
    Meghani, Khyati
    Leggett, Alan L.
    Qi, Jun
    Shapiro, Geoffrey I.
    Liu, Joyce F.
    Matulonis, Ursula A.
    Lin, Charles Y.
    Konstantinopoulos, Panagiotis A.
    Gray, Nathanael S.
    ELIFE, 2018, 7
  • [16] Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer
    Dieter, Sebastian M.
    Siegl, Christine
    Codo, Paula L.
    Huerta, Mario
    Ostermann-Parucha, Anna L.
    Schulz, Erik
    Zowada, Martina K.
    Martin, Sylvia
    Laaber, Karin
    Nowrouzi, Ali
    Blatter, Mona
    Kreth, Sina
    Westermann, Frank
    Benner, Axel
    Uhrig, Ulrike
    Putzker, Kerstin
    Lewis, Joe
    Haegebarth, Andrea
    Mumberg, Dominik
    Holton, Simon J.
    Weiske, Joerg
    Toepper, Lena-Marit
    Scheib, Ulrike
    Siemeister, Gerhard
    Ball, Claudia R.
    Kuster, Bernhard
    Stoehr, Gabriele
    Hahne, Hannes
    Johannes, Sarah
    Lange, Martin
    Herbst, Friederike
    Glimm, Hanno
    CELL REPORTS, 2021, 36 (03):
  • [17] Discovery of a highly potent and selective dual PROTAC degrader of CDK12 and CDK13
    Chang, Yu
    Yang, Jianzhang
    Tien, Jean Ching-Yi
    Wang, Zhen
    Zhou, Yang
    Zhang, Pujuan
    Huang, Weixue
    Vo, Josh
    Apel, Ingrid J.
    Wang, Cynthia
    Zeng, Victoria Zhixuan
    Cheng, Yunhui
    Li, Shuqin
    Wang, George Xiaoju
    Ding, Ke
    Chinnaiyan, Arul M.
    CANCER RESEARCH, 2023, 83 (07)
  • [18] Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13
    Yang, Jianzhang
    Chang, Yu
    Tien, Jean Ching-Yi
    Wang, Zhen
    Zhou, Yang
    Zhang, Pujuan
    Huang, Weixue
    Vo, Josh
    Apel, Ingrid J.
    Wang, Cynthia
    Zeng, Victoria Zhixuan
    Cheng, Yunhui
    Wang, George Xiaoju
    Chinnaiyan, Arul M.
    Ding, Ke
    JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (16) : 11066 - 11083
  • [20] CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival
    Lier, S.
    Rein, I
    Lund, S.
    Lang, A.
    Lang, E.
    Meyer, N.
    Dutta, A.
    Anand, S.
    Nesse, G.
    Johansen, R.
    Klungland, A.
    Rinholm, J.
    Boe, S.
    Anand, A.
    Pollard, S.
    Lerdrup, M.
    Pandey, D.
    NEURO-ONCOLOGY, 2022, 24