Indirect effects of cytomegalovirus infection: Implications for vaccine development

被引：7

作者：

Moseley, Philip ^{[1
]}

Klenerman, Paul ^{[2
,3
]}

Kadambari, Seilesh ^{[4
,5
,6
,7
]}

机构：

[1] Oxford Univ Hosp, Horton Gen Hosp, Dept Paediat, Banbury, England

[2] Univ Oxford, Translat Gastroenterol Unit, Oxford, England

[3] Univ Oxford, Nuffield Dept Med, Oxford, England

[4] Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, England

[5] NIHR Oxford Biomed Res Ctr, Oxford, England

[6] Great Ormond St Hosp Children NHS Fdn Trust, Dept Paediat Infect Dis, London, England

[7] UCL, Great Ormond St Inst Child Hlth, London, England

来源：

REVIEWS IN MEDICAL VIROLOGY | 2023年 / 33卷 / 01期

关键词：

T-LYMPHOCYTE SUBPOPULATIONS; INFLUENZA VACCINATION; PERIPHERAL-BLOOD; ATHEROSCLEROSIS RISK; COST-EFFECTIVENESS; ADOLESCENT GIRLS; ANTIBODY-LEVELS; CELL RESPONSES; DOUBLE-BLIND; OLD-AGE;

D O I：

10.1002/rmv.2405

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Development of a cytomegalovirus (CMV) vaccine is a high priority due to its significant global impact-contributing to mortality in immunosuppressed individuals, neurodevelopmental delay in infected neonates and non-genetic sensorineural hearing loss. The impact of CMV on the general population has been less well studied; however, a wide range of evidence indicates that CMV may increase the risk of atherosclerosis, cancer, immunosenescence, and progression of tuberculosis (TB) and human immunodeficiency virus. Due to the high seroprevalence of CMV worldwide, any modulation of risk by CMV is likely to have a significant impact on the epidemiology of these diseases. This review will evaluate how CMV may cause morbidity and mortality outside of the neonatal and immunosuppressed populations and consider the potential impact of a CMV vaccine on these outcomes.

引用

页数：14

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