Access to N-Difluoromethyl Amides, (Thio)Carbamates, Ureas, and Formamides

被引：6

作者：

Zivkovic, Filip G. ^{[1
]}

Wycich, Gina ^{[1
]}

Liu, Linhao ^{[1
]}

Schoenebeck, Franziska ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2024年 / 146卷 / 02期

基金：

欧洲研究理事会;

关键词：

TRIFLUOROMETHYL AMIDES; O-DIFLUOROMETHYLATION; FLUORINE; IMIDAZOLES; REAGENT; AMINES;

D O I：

10.1021/jacs.3c13711

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first efficient access to N-difluoromethyl amides, carbamates, thiocarbamates, ureas, formamides, and their derivatives is reported herein. The synthetic strategy relies on the initial synthesis and straightforward derivatization of N-CF2H carbamoyl fluorides, which were prepared through a desulfurization-fluorination of thioformamides (& horbar;NH & horbar;C(H)& boxH;S) coupled with carbonylation. The newly made N-CF2H carbonyl compounds proved to be highly robust and compatible with numerous chemical transformations and downstream derivatizations, underscoring the potential of this novel motif as a building block in complex functional molecules.

引用

页码：1276 / 1281

页数：6

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