Triglyceride induces DNA damage leading to monocyte death by activating caspase-2 and caspase-8

被引：4
|
作者：
Jung, Byung Chul [1 ,2 ]
Kim, Hyun-Kyung [2 ,3 ]
Kim, Sung Hoon [2 ,4 ]
Kim, Yoon Suk [2 ]
机构：
[1] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA
[2] Yonsei Univ, Coll Software & Digital Healthcare Convergence, Dept Biomed Lab Sci, Wonju 26493, South Korea
[3] Gimcheon Univ, Coll Nat Sci, Dept Biomed Lab Sci, Gimcheon 39528, South Korea
[4] Korea Nazarene Univ, Dept Biomed Lab Sci, Cheonan 31172, South Korea
来源：
BMB REPORTS | 2023年 / 56卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
CELL-DEATH; OXIDATIVE STRESS; APOPTOSIS; TRIACYLGLYCEROLS; CHOLESTEROL; MACROPHAGES;
D O I：
10.5483/BMBRep.2022-0201
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Monocytes are peripheral leukocytes that function in innate immunity. Excessive triglyceride (TG) accumulation causes monocyte death and thus can compromise innate immunity. However, the mechanisms by which TG mediates monocyte death remain unclear to date. Thus, this study aimed to elucidate the mechanisms by which TG induces monocyte death. Results showed that TG induced monocyte death by activating caspase-3/7 and promoting poly (ADP-ribose) polymerase (PARP) cleavage. In addition, TG induced DNA damage and activated the ataxia telangiectasia mutated (ATM)/checkpoint kinase 2 and ATM-and Rad3-related (ATR)/checkpoint kinase 1 pathways, leading to the cell death. Furthermore, TG-induced DNA dam-age and monocyte death were mediated by caspase-2 and-8, and caspase-8 acted as an upstream molecule of caspase-2. Taken together, these results suggest that TG-induced monocyte death is mediated via the caspase-8/caspase-2/DNA damage/ executioner caspase/PARP pathways. [BMB Reports 2023; 56(3): 166-171]
引用
收藏
页码：166 / 171
页数：6
相关论文
共 50 条
  • [21] Cardiolipin provides an essential activating platform for caspase-8 on mitochondria
    Gonzalvez, Francois
    Schug, Zachary T.
    Houtkooper, Riekelt H.
    MacKenzie, Elaine D.
    Brooks, David G.
    Wanders, Ronald J. A.
    Petit, Patrice X.
    Vaz, Frederic M.
    Gottlieb, Eyal
    JOURNAL OF CELL BIOLOGY, 2008, 183 (04): : 681 - 696
  • [22] TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3
    Espin, Raquel
    Roca, Francisco J.
    Candel, Sergio
    Sepulcre, Maria P.
    Gonzalez-Rosa, Juan M.
    Alcaraz-Perez, Francisca
    Meseguer, Jose
    Cayuela, Maria L.
    Mercader, Nadia
    Mulero, Victoriano
    DISEASE MODELS & MECHANISMS, 2013, 6 (02) : 383 - 396
  • [23] Oxidative stress induces activation of mitochondrial caspase-2
    Sun, M
    Centonze, VE
    Herman, B
    MOLECULAR BIOLOGY OF THE CELL, 2001, 12 : 275A - 275A
  • [24] Hydrogen peroxide induces apoptosis in astrocytes. Activation of caspase-8 and caspase-3
    Quaglino, A
    Armanino, MV
    Kotler, ML
    Juknat, AA
    JOURNAL OF NEUROCHEMISTRY, 2001, 78 : 126 - 126
  • [25] Caspase-2 protects against ferroptotic cell death
    Dawar, Swati
    Benitez, Mariana C.
    Lim, Yoon
    Dite, Toby A.
    Yousef, Jumana M.
    Thio, Niko
    Garciaz, Sylvain
    Jackson, Thomas D.
    Milne, Julia V.
    Dagley, Laura F.
    Phillips, Wayne A.
    Kumar, Sharad
    Clemons, Nicholas J.
    CELL DEATH & DISEASE, 2024, 15 (03)
  • [26] FOXO3 induces silenced caspase-8 in neuroblastoma
    Geiger, Kathrin
    Hagenbuchner, Judith
    Rupp, Martina
    Fiegl, Heidi
    Sergi, Consolato
    Ausserlechner, Michael J.
    Obexer, Petra
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2012, 30 : S42 - S42
  • [27] Compressive force induces osteoblast apoptosis via caspase-8
    Goga, Y
    Chiba, M
    Shimizu, Y
    Mitani, H
    JOURNAL OF DENTAL RESEARCH, 2006, 85 (03) : 240 - 244
  • [28] Caspase-2 protects against ferroptotic cell death
    Swati Dawar
    Mariana C. Benitez
    Yoon Lim
    Toby A. Dite
    Jumana M. Yousef
    Niko Thio
    Sylvain Garciaz
    Thomas D. Jackson
    Julia V. Milne
    Laura F. Dagley
    Wayne A. Phillips
    Sharad Kumar
    Nicholas J. Clemons
    Cell Death & Disease, 15
  • [29] Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock
    Manda, Pratyusha
    Feng, Yanjun
    Lyons, John D.
    Berger, Scott B.
    Otani, Shunsuke
    DeLaney, Alexandra
    Tharp, Gregory K.
    Maner-Smith, Kristal
    Burd, Eileen M.
    Schaeffer, Michelle
    Hoffman, Sandra
    Capriotti, Carol
    Roback, Linda
    Young, Cedrick B.
    Liang, Zhe
    Ortlund, Eric A.
    DiPaolo, Nelson C.
    Bosinger, Steven
    Bertin, John
    Gough, Peter J.
    Brodsky, Igor E.
    Coopersmith, Craig M.
    Shayakhmetov, Dmitry M.
    Mocarski, Edward S.
    IMMUNITY, 2018, 49 (01) : 42 - +
  • [30] vFLIP, a Viral Regulator of Caspase-8, Induces Acute, Death Mediated Liver Damage That Promotes Chronic Fibrotic Liver Disease
    Guenther, Claudia
    Wirtz, Stefan J.
    Neurath, Markus F.
    Neumann, Helmut
    Becker, Christoph
    GASTROENTEROLOGY, 2014, 146 (05) : S925 - S925
12345