DNA sensing in the pathological process of ischemic stroke

被引：2

作者：

Zhang, Shi W. ^{[1
]}

Wu, Chao R. ^{[1
]}

Liao, Hong ^{[1
]}

机构：

[1] China Pharmaceut Univ, New Drug Screening Ctr, Jiangsu Ctr Pharmacodynam Res & Evaluat, Nanjing 210009, Peoples R China

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 2023年 / 57卷 / 08期

基金：

中国国家自然科学基金;

关键词：

abnormal DNA; DNA sensors; inflammatory response; innate immune response; ischemic stroke; GMP-AMP SYNTHASE; NF-KAPPA-B; SIGNALING PATHWAY; AIM2; INFLAMMASOME; PATTERN-RECOGNITION; BRAIN-INJURY; ACTIVATION; RECEPTOR; CGAS; TLR9;

D O I：

10.1111/ejn.15967

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The innate immune response plays an important role in the pathological process of ischemic stroke. Increasing evidence suggests that the inflammatory response triggered by the innate immune system hinders neurological and behavioural recovery after stroke. The perception of abnormal DNA and its downstream effects are an essential part of the innate immune system. The abnormal DNA is the major inducing factor for innate immune response and is sensed by a series of DNA sensors. In this review, we discussed the multiple roles of DNA sensing in the pathological process of ischemic stroke, with a special focus on DNA sensors Toll-like receptor 9 (TLR9), absent in melanoma 2 (AIM2) and cyclic GMP-AMP synthase (cGAS).

引用

页码：1432 / 1441

页数：10

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