Secondary metabolites from the marine-derived fungus Penicillium chrysogenum Y20-2, and their pro-angiogenic activity

被引：3
|
作者：
Qiu, Yue-Zi [1 ]
Zhu, Yong-Qiang [1 ]
Lu, Hong [2 ]
Li, Xiao-Bin [1 ]
Liu, Ke-Chun [1 ]
Li, Pei-Hai [1 ]
Wang, Li-Zhen [1 ]
Zhang, Xuan-Ming [1 ]
Chen, Hao [3 ]
Lin, Hou-Wen [4 ]
Zhang, Shan-Shan [1 ]
机构：
[1] Qilu Univ Technol, Shandong Prov Engn Lab Biol Testing Technol, Engn Res Ctr Zebrafish Models Human Dis & Drug Sc, Shandong Acad Sci,Biol Inst, Jinan 250103, Peoples R China
[2] Yucheng Peoples Hosp, Dezhou 253000, Peoples R China
[3] Minist Nat Resources, Inst Oceanog 1, Key Lab Marine Bioact Subst, Qingdao 266061, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Med, Res Ctr Marine Drugs, State Key Lab Oncogenes & Related Genes, Shanghai 200127, Peoples R China
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2023年 / 78卷 / 9-10期
关键词：
bioactive metabolite; marine-derived fungus; Penicillium chrysogenum; pro-angiogenesis; STRUCTURE ELUCIDATION; PRODUCTS; CONSTITUENTS; MELEAGRIN; ESTER;
D O I：
10.1515/znc-2022-0198
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A systematic chemical study of the secondary metabolites of the marine fungus, Penicillium chrysogenum (No. Y20-2), led to the isolation of 21 compounds, one of which is new (compound 3). The structures of the 21 compounds were determined by conducting extensive analysis of the spectroscopic data. The pro-angiogenic activity of each compound was evaluated using a zebrafish model. The results showed that compounds 7, 9, 16, and17 had strong and dose-dependent pro-angiogenic effects, with compound 16 demonstrating the strongest pro-angiogenic activity, compounds 6, 12, 14, and 18 showing moderate activity, and compounds 8, 13, and 19 exhibiting relatively weak activity.
引用
收藏
页码：345 / 352
页数：8
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