Taking the STING out of CIN

被引：0

作者：

van den Brink, Anouk ^{[1
]}

Foijer, Floris ^{[1
,2
]}

机构：

[1] Univ Groningen, European Res Inst Biol Ageing, NL-9713 AV Groningen, Netherlands

[2] Univ Med Ctr Groningen, Groningen, Netherlands

来源：

TRENDS IN CANCER | 2023年 / 9卷 / 12期

关键词：

CHROMOSOMAL INSTABILITY;

D O I：

10.1016/j.trecan.2023.09.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosomal instability (CIN), a hallmark of cancer, promotes cell-intrinsic inflammatory signaling. Although inflammation is generally considered tumor-suppressive, this relationship is more complex in cancers with CIN. We discuss new findings by Li et al. that can explain how cancer cells with CIN tolerate, adopt, and rewire the CIN-induced inflammatory response to fuel tumorigenesis.

引用

页码：992 / 994

页数：3

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