Bullous Pemphigoid in X-linked Alport Syndrome

被引：2

作者：

Yamawaki, Masahiro ^{[1
]}

Katayama, Kan ^{[1
]}

Fujimoto, Mika ^{[1
]}

Goto, Hiroyuki ^{[2
]}

Yuasa, Hiroto ^{[3
]}

Kozuka, Yuji ^{[3
]}

Mori, Mutsuki ^{[1
]}

Takahashi, Daisuke ^{[1
]}

Saiki, Ryosuke ^{[1
]}

Hirabayashi, Yosuke ^{[1
]}

Murata, Tomohiro ^{[1
]}

Yamanaka, Keiichi ^{[2
]}

Dohi, Kaoru ^{[1
]}

机构：

[1] Mie Univ, Dept Cardiol & Nephrol, Grad Sch Med, Tsu, Japan

[2] Mie Univ, Dept Dermatol, Grad Sch Med, Tsu, Japan

[3] Mie Univ Hosp, Dept Pathol, Tsu, Japan

来源：

INTERNAL MEDICINE | 2023年 / 62卷 / 16期

关键词：

basement membrane zone; bullous pemphigoid; X-linked Alport syndrome; SUBEPIDERMAL BLISTERS; COLLAGEN; IV; IDENTIFICATION; AUTOANTIBODIES; MUTATIONS; ALPHA-5;

D O I：

10.2169/internalmedicine.0972-22

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Skin lesions in X-linked Alport syndrome (XLAS) are rarely observed. Bullous pemphigoid (BP) is caused by autoantibodies against BP180, also called & alpha;1 (XVII) chain, in the basement membrane zone (BMZ). A 48-year-old man with XLAS developed tense blisters. A skin biopsy showed a cleft between the basal cell layer and dermis, with the infiltration of neutrophils and eosinophils. & alpha;1 (XVII) staining was positive on the epidermal side of & alpha;2/5 (IV) staining. Oral prednisolone improved his symptoms gradually. Abundant tense blisters on the palms and soles might suggest an important role of the & alpha;5 (IV) chain in the integrity of BMZ.

引用

页码：2375 / 2379

页数：5

共 50 条

[41] Gene expression analysis in a canine model of X-linked Alport syndrome
Kimberly A. Greer
Marnie A. Higgins
Melissa L. Cox
Timothy P. Ryan
Brian R. Berridge
Clifford E. Kashtan
George E. Lees
Keith E. Murphy
Mammalian Genome, 2006, 17 : 976 - 990
[42] IgA nephropathy in patient with X-linked Alport syndrome - a case report
Horacek, M.
Pavic, P.
Senjug, P.
Martic, T. Nikuseva
Maksimovic, B.
Simunov, B.
Ljubanovic, D. Galesic
VIRCHOWS ARCHIV, 2021, 479 : S273 - S273
[43] The Value of Clinical Criteria in Identifying Patients with X-Linked Alport Syndrome
Hanson, Helen
Storey, Helen
Pagan, Judith
Flinter, Frances
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 6 (01): : 198 - 203
[44] Germline mosaicism is a pitfall in the diagnosis of "sporadic" X-linked Alport syndrome
Okamoto, Takayuki
Nozu, Kandai
Iijima, Kazumoto
Ariga, Tadashi
JOURNAL OF NEPHROLOGY, 2019, 32 (01) : 155 - 159
[45] Germline mosaicism is a pitfall in the diagnosis of “sporadic” X-linked Alport syndrome
Takayuki Okamoto
Kandai Nozu
Kazumoto Iijima
Tadashi Ariga
Journal of Nephrology, 2019, 32 : 155 - 159
[46] Genetic cause of X-linked Alport syndrome in a family of domestic dogs
Cox, ML
Lees, GE
Kashtan, CE
Murphy, KE
MAMMALIAN GENOME, 2003, 14 (06) : 396 - 403
[47] Glomerular expression of type TV collagen in X-linked Alport syndrome
Heidet, L
Cai, Y
Guicharnaud, L
Antignac, C
Gubler, MC
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1999, 113 (06) : 1145 - 1145
[48] Gene expression analysis in a canine model of X-linked Alport syndrome
Greer, Kimberly A.
Higgins, Marnie A.
Cox, Melissa L.
Ryan, Timothy P.
Berridge, Brian R.
Kashtan, Clifford E.
Lees, George E.
Murphy, Keith E.
MAMMALIAN GENOME, 2006, 17 (09) : 976 - 990
[49] Characterization of the peripheral retinopathy in X-linked and autosomal recessive Alport syndrome
Shaw, Elizabeth A.
Colville, Deb
Wang, Yan Yan
Zhang, Ke Wei
Dagher, Hayat
Fassett, Rob
Guymer, Robyn
Savige, Judy
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2007, 22 (01) : 104 - 108
[50] Clinical and genetic features in autosomal recessive and X-linked Alport syndrome
Yanyan Wang
Vanessa Sivakumar
Mardhiah Mohammad
Deb Colville
Helen Storey
Frances Flinter
Hayat Dagher
Judy Savige
Pediatric Nephrology, 2014, 29 : 391 - 396

← 1 2 3 4 5 →