Measuring the impact of chromatin context on transcription factor binding affinities

被引：0

作者：

Lindeboom, Rik G. H. ^{[1
]}

Neikes, Hannah K. ^{[2
]}

机构：

[1] Netherlands Canc Inst, Amsterdam, Netherlands

[2] Radboud Inst Mol Life Sci, Nijmegen, Netherlands

来源：

NATURE BIOTECHNOLOGY | 2023年 / 41卷 / 12期

关键词：

D O I：

10.1038/s41587-023-01752-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have designed a method, binding affinities to native chromatin by sequencing (BANC-seq), to determine the transcription factor concentrations required for binding to regulatory elements across the genome. Our study shows that chromatin context and DNA accessibility are key regulators of transcription factor binding.

引用

页码：1696 / 1697

页数：2

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