An efficient synthesis of novel coumarinyldihydropyrimidin-2-thiones via coumarinylenones

被引：1

作者：

Tyagi, Abhilash ^{[1
]}

Mahiya, Kuldeep ^{[1
,2
]}

Kumar, Rajesh ^{[3
,5
]}

Singh, Sukhdev ^{[1
,4
,6
]}

机构：

[1] Univ Delhi, Dept Chem, Bioorgan Lab, Delhi, India

[2] FGM Govt Coll, Dept Chem, Adampur Hisar, Haryana, India

[3] BRA Bihar Univ, RDS Coll, PG Dept Chem, Muzaffarpur, Bihar, India

[4] GSSS Hizrawan Khurd 3371, Directorate Secondary Educ, Fatehabad, Haryana, India

[5] BRA Bihar Univ, RDS Coll, PG Dept Chem, Muzaffarpur 842002, Bihar, India

[6] Univ Delhi, Dept Chem, Bioorgan Lab, Delhi 110007, India

来源：

SYNTHETIC COMMUNICATIONS | 2024年 / 54卷 / 01期

关键词：

4-formylcoumarin; Lewis acid catalyst; coumarinyl-DHPM; Knoevenagel condensation; 2-thioxo-3,4-dihydropyrimidine; CALCIUM-CHANNEL BLOCKERS; ONE-STEP SYNTHESIS; ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; BIOLOGICAL EVALUATION; DERIVATIVES; DIHYDROPYRIMIDINES; INHIBITORS; ACETYLCHOLINESTERASE; ANTIBACTERIAL;

D O I：

10.1080/00397911.2023.2280576

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel coumarinyldihydropyrimidin-2-thiones (coumarinyl-DHPM) have been synthesized by Knoevenagel condensation of 4-formylcoumarins with different beta-keto esters in the presence of aluminum chloride (AlCl3) as Lewis acid catalyst leading to coumarinylenones followed by cyclization with protected thiourea and subsequent deprotection of protected sulfur intermediate by trifluoroacetic acid. The structures of coumarinylenones, protected intermediate and the desired coumarinyl-DHPM were confirmed by their NMR and X-ray diffraction analysis. [GRAPHICS]

引用

页码：41 / 49

页数：9

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