Association of serum vitamin D concentration with the final course of hospitalization in patients with COVID-19

被引:3
|
作者
Konikowska, Klaudia [1 ]
Kilis-Pstrusinska, Katarzyna [2 ]
Matera-Witkiewicz, Agnieszka [3 ]
Kujawa, Krzysztof [4 ]
Adamik, Barbara [5 ]
Doroszko, Adrian [6 ]
Kaliszewski, Krzysztof [7 ]
Pomorski, Michal [8 ]
Protasiewicz, Marcin [9 ]
Sokolowski, Janusz [10 ]
Madziarska, Katarzyna [11 ]
Jankowska, Ewa Anita [9 ,12 ]
机构
[1] Wroclaw Med Univ, Dept Dietet & Bromatol, Wroclaw, Poland
[2] Wroclaw Med Univ, Clin Dept Paediat Nephrol, Wroclaw, Poland
[3] Wroclaw Med Univ, Wroclaw Med Univ Biobank, Screening Biol Act Assays & Collect Biol Mat Lab, Wroclaw, Poland
[4] Wroclaw Med Univ, Stat Anal Ctr, Wroclaw, Poland
[5] Wroclaw Med Univ, Clin Dept Anaesthesiol & Intens Therapy, Wroclaw, Poland
[6] Wroclaw Med Univ, Clin Dept Internal & Occupat Dis, Hypertens & Clin Oncol, Wroclaw, Poland
[7] Wroclaw Med Univ, Dept Gen Minimally Invas & Endocrine Surg, Wroclaw, Poland
[8] Wroclaw Med Univ, Clin Dept Gynecol & Obstet, Wroclaw, Poland
[9] Wroclaw Med Univ, Inst Heart Dis, Wroclaw, Poland
[10] Wroclaw Med Univ, Clin Dept Emergency Med, Wroclaw, Poland
[11] Wroclaw Med Univ, Clin Dept Nephrol & Transplantat Med, Wroclaw, Poland
[12] Univ Hosp, Inst Heart Dis, Wroclaw, Poland
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词
SARS-CoV-2; vitamin D; COVID-19; mortality; vitamin D deficiency; public health; CHRONIC KIDNEY-DISEASE; D DEFICIENCY; D SUPPLEMENTATION; RISK; POPULATION; PREVALENCE; GUIDELINES; DISORDERS; INJURY; ANOVA;
D O I
10.3389/fimmu.2023.1231813
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: Vitamin D deficiency is a substantial public health problem. The present study evaluated the association between vitamin D concentration and hospitalization and mortality risk in patients with coronavirus disease 19 (COVID-19).Methods: This study used the COronavirus in LOwer Silesia (COLOS) dataset collected between February 2020 and June 2021. The medical records of 474 patients with confirmed severe acute respiratory syndrome 2 (SARS-CoV-2) infection, and whose vitamin D concentration was measured, were analyzed.Results: We determined a significant difference in vitamin D concentration between discharged patients and those who died during hospitalization (p = 0.0096). We also found an effect of vitamin D concentration on the risk of death in patients hospitalized due to COVID-19. As vitamin D concentration increased, the odds ratio (OR) for death slightly decreased (OR = 0.978; 95% confidence interval [CI] = 0.540-0.669). The vitamin D concentration cutoff point was 15.40 ng/ml. In addition, patients with COVID-19 and serum 25-hydroxyvitamin D (25(OH)D) concentrations < 30 ng/ml had a lower survival rate than those with serum 25(OH)D =30 ng/ml (log-rank test p = 0.0018). Moreover, a Cox regression model showed that patients with an estimated glomerular filtration rate (eGFR) =3; 60 ml/min/1.73 m(2) and higher vitamin D concentrations had a 2.8% reduced risk of mortality (hazard ratio HR = 0.972; CI = 0.95-0,99; p = 0.0097).Conclusions: The results indicate an association between 25(OH)D levels in patients with COVID-19 and the final course of hospitalization and risk of death.
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页数:11
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