AnnexinA6: a potential therapeutic target gene for extracellular matrix mineralization

被引:6
|
作者
Yang, Jie [1 ]
Pei, Tong [1 ]
Su, Guanyue [1 ]
Duan, Peiyan [1 ]
Liu, Xiaoheng [1 ]
机构
[1] Sichuan Univ, Inst Biomed Engn, West China Sch Basic Med Sci & Forens Med, Chengdu, Peoples R China
基金
中国国家自然科学基金;
关键词
AnnexinA6; Ca2+ regulation; matrix vesicles; extracellular matrix mineralization; osteogenesis; bone regeneration; VESICLE-MEDIATED MINERALIZATION; GROWTH-PLATE CARTILAGE; ARTERIAL CALCIFICATION; VASCULAR CALCIFICATION; ALKALINE-PHOSPHATASE; CELL-PROLIFERATION; NUCLEATIONAL CORE; CRYSTAL-STRUCTURE; MEMBRANE-BINDING; DOWN-REGULATION;
D O I
10.3389/fcell.2023.1201200
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The mineralization of the extracellular matrix (ECM) is an essential and crucial process for physiological bone formation and pathological calcification. The abnormal function of ECM mineralization contributes to the worldwide risk of developing mineralization-related diseases; for instance, vascular calcification is attributed to the hyperfunction of ECM mineralization, while osteoporosis is due to hypofunction. AnnexinA6 (AnxA6), a Ca2+-dependent phospholipid-binding protein, has been extensively reported as an essential target in mineralization-related diseases such as osteoporosis, osteoarthritis, atherosclerosis, osteosarcoma, and calcific aortic valve disease. To date, AnxA6, as the largest member of the Annexin family, has attracted much attention due to its significant contribution to matrix vesicles (MVs) production and release, MVs-ECM interaction, cytoplasmic Ca2+ influx, and maturation of hydroxyapatite, making it an essential target in ECM mineralization. In this review, we outlined the recent advancements in the role of AnxA6 in mineralization-related diseases and the potential mechanisms of AnxA6 under normal and mineralization-related pathological conditions. AnxA6 could promote ECM mineralization for bone regeneration in the manner described previously. Therefore, AnxA6 may be a potential osteogenic target for ECM mineralization.
引用
收藏
页数:13
相关论文
共 50 条
  • [31] CXCL6: A potential therapeutic target for inflammation and cancer
    Chun-Lan Dai
    Hong-Xuan Yang
    Qiu-Ping Liu
    Khalid Rahman
    Hong Zhang
    Clinical and Experimental Medicine, 2023, 23 : 4413 - 4427
  • [32] LDHA mediated degradation of extracellular matrix is a potential target for the treatment of aortic dissection
    Wu, Xiaohui
    Ye, Jianqiang
    Cai, Weixing
    Yang, Xi
    Zou, Qiuying
    Lin, Jingjing
    Zheng, Hui
    Wang, Chaoyun
    Chen, Liangwan
    Li, Yumei
    PHARMACOLOGICAL RESEARCH, 2022, 176
  • [33] Hypothermia Identifies Extracellular Calcium-sensing Receptor (CaSR) As A Potential Therapeutic Target
    Kim, Jong Youl
    Kim, Nuri
    Yenari, Midori A.
    Chang, Wenhan
    STROKE, 2011, 42 (03) : E215 - E215
  • [34] Neutrophil Extracellular Traps: A Potential Therapeutic Target in MPO-ANCA Associated Vasculitis?
    O'Sullivan, Kim M.
    Holdsworth, Stephen R.
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [35] Extracellular Signal-Regulated Kinase 5: A Potential Therapeutic Target for Malignant Mesotheliomas
    Shukla, Arti
    Miller, Jill M.
    Cason, Christopher
    Sayan, Mutlay
    MacPherson, Maximilian B.
    Beuschel, Stacie L.
    Hillegass, Jedd
    Vacek, Pamela M.
    Pass, Harvey I.
    Mossman, Brooke T.
    CLINICAL CANCER RESEARCH, 2013, 19 (08) : 2071 - 2083
  • [36] Surface α-Enolase Promotes Extracellular Matrix Degradation and Tumor Metastasis and Represents a New Therapeutic Target
    Hsiao, Kuan-Chung
    Shih, Neng-Yao
    Fang, Hsun-Lang
    Huang, Tze-Sing
    Kuo, Ching-Chuan
    Chu, Pei-Yi
    Hung, Yi-Mei
    Chou, Shao-Wen
    Yang, Yi-Yuan
    Chang, Gee-Chen
    Liu, Ko-Jiunn
    PLOS ONE, 2013, 8 (07):
  • [37] Myocardial matrix degradation and metalloproteinase activation in the failing heart: a potential therapeutic target
    Spinale, FG
    Coker, ML
    Bond, BR
    Zellner, JL
    CARDIOVASCULAR RESEARCH, 2000, 46 (02) : 225 - 238
  • [38] Tumor suppressor gene PTEN in prostate cancer: A potential therapeutic target
    Magi-Galluzzi, C
    Skacel, M
    Sercia, L
    Garcia, J
    Reuther, A
    Klein, E
    Dreicer, R
    Zhou, M
    MODERN PATHOLOGY, 2006, 19 : 148A - 148A
  • [39] Gene A, upregulated by mutant KRAS, is a potential therapeutic target for lung cancer
    Kawabe, Nozomi
    Muraki, Nao
    Tanaka, Ichidai
    Sunaga, Noriaki
    Sato, Mitsuo
    CANCER SCIENCE, 2024, 115 : 1547 - 1547
  • [40] Therapeutic potential of CPT I inhibitors: cardiac gene, transcription as a target
    Zarain-Herzberg, A
    Rupp, H
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2002, 11 (03) : 345 - 356