3D Printed Template-Assisted Casting of Biocompatible Polyvinyl Alcohol-Based Soft Microswimmers with Tunable Stability

被引：17
|
作者：
Sanchis-Gual, Roger [1 ]
Ye, Hao [1 ]
Ueno, Towa [1 ]
Landers, Fabian C. [1 ]
Hertle, Lukas [1 ]
Deng, Siyu [1 ]
Veciana, Andrea [1 ]
Xia, Yanming [2 ]
Franco, Carlos [1 ]
Choi, Hongsoo [3 ]
Puigmarti-Luis, Josep [4 ,5 ]
Nelson, Bradley J. [1 ]
Chen, Xiang-Zhong [1 ]
Pane, Salvador [1 ]
机构：
[1] Swiss Fed Inst Technol, Inst Robot & Intelligent Syst, Multiscale Robot Lab, Tannenstr 3, CH-8092 Zurich, Switzerland
[2] Xiamen Univ, Dept Mech & Elect Engn, Xiamen 361005, Peoples R China
[3] Daegu Gyeongbuk Inst Sci & Technol DGIST, ETH Microrobot Res Ctr, Dept Robot & Mechatron Engn, 333 Techno Jungang Daero, Daegu 42988, South Korea
[4] Univ Barcelona UB, Inst Quim Teor & Computac, Dept Ciencia dels Mat & Quim Fis, Barcelona 08028, Spain
[5] ICREA Inst Catalana Reserca & Estudis Avancats, Pg Lluis Co 23, Barcelona 08010, Spain
来源：
ADVANCED FUNCTIONAL MATERIALS | 2023年 / 33卷 / 39期
基金：
瑞士国家科学基金会; 欧洲研究理事会; 新加坡国家研究基金会;
关键词：
3D printing; biocompatibility; hydrogels; microrobots; salting out; BIODEGRADATION; HYDROGELS; MICRO;
D O I：
10.1002/adfm.202212952
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The past decade has seen an upsurge in the development of small-scale magnetic robots for various biomedical applications. However, many of the reported designs comprise components with biocompatibility concerns. Strategies for fabricating biocompatible and degradable microrobots are required. In this study, polyvinyl alcohol (PVA)-based magnetic hydrogel microrobots with different morphologies and tunable stability are developed by combining a 3D printed template-assisted casting with a salting-out process. 3D sacrificial micromolds are prepared via direct laser writing to shape PVA-magnetic nanoparticle composite hydrogel microrobots with high architectural complexity. By adjusting the PVA composition and salting-out parameters, the hydrogel dissolubility can be customized. Due to their high mobility, tunable stability, and high biocompatibility, these PVA-based magnetic microrobots are suitable platforms for targeted drug and cell delivery.
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页数：10
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