Allopregnanolone as a Regenerative Therapeutic for Alzheimer's Disease (AD): A phase 2 proof-of-concept clinical trial using hippocampal volume as a surrogate endpoint

被引：0
|
作者：
Rivera, Gerson Hernandez [1 ]
Lopez, Claudia [1 ]
Raikes, Adam [1 ]
Rodgers, Kathleen [1 ]
Matthews, Dawn [2 ]
Schneider, Lon [3 ]
Brinton, Roberta [1 ]
机构：
[1] Univ Arizona, Ctr Innovat Brain Sci, Tucson, AZ USA
[2] ADM Diagnost, Northbrook, IL USA
[3] USC Sch Med, Los Angeles, CA USA
来源：
NEUROLOGY | 2023年 / 100卷 / 17期
关键词：
D O I：
10.1212/WNL.0000000000202953
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
P8-6.008
引用
收藏
页数：3
相关论文
共 50 条
  • [31] Lecanemab in patients with early Alzheimer's disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study
    McDade, Eric
    Cummings, Jeffrey L.
    Dhadda, Shobha
    Swanson, Chad J.
    Reyderman, Larisa
    Kanekiyo, Michio
    Koyama, Akihiko
    Irizarry, Michael
    Kramer, Lynn D.
    Bateman, Randall J.
    ALZHEIMERS RESEARCH & THERAPY, 2022, 14 (01)
  • [32] Lecanemab in patients with early Alzheimer’s disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study
    Eric McDade
    Jeffrey L. Cummings
    Shobha Dhadda
    Chad J. Swanson
    Larisa Reyderman
    Michio Kanekiyo
    Akihiko Koyama
    Michael Irizarry
    Lynn D. Kramer
    Randall J. Bateman
    Alzheimer's Research & Therapy, 14
  • [33] A proof-of-concept, Phase 2 clinical trial of the gastrointestinal safety of a hydrogen sulfide-releasing anti-inflammatory drug
    Wallace, John L.
    Nagy, Peter
    Feener, Troy D.
    Allain, Thibault
    Ditroi, Tamas
    Vaughan, David J.
    Muscara, Marcelo N.
    de Nucci, Gilberto
    Buret, Andre G.
    BRITISH JOURNAL OF PHARMACOLOGY, 2020, 177 (04) : 769 - 777
  • [34] Synovial tissue and serum biomarkers of disease activity, therapeutic response and radiographic progression: analysis of a proof-of-concept randomised clinical trial of cytokine blockade
    Rooney, Terence
    Roux-Lombard, Pascale
    Veale, Douglas J.
    FitzGerald, Oliver
    Dayer, Jean-Michel
    Bresnihan, Barry
    ANNALS OF THE RHEUMATIC DISEASES, 2010, 69 (04) : 706 - 714
  • [35] Effect of masupirdine (SUVN-502) on cognition in patients with moderate Alzheimer's disease: A randomized, double-blind, phase 2, proof-of-concept study
    Nirogi, Ramakrishna
    Ieni, John
    Goyal, Vinod Kumar
    Ravula, Jyothsna
    Jetta, Satish
    Shinde, Anil
    Jayarajan, Pradeep
    Benade, Vijay
    Palacharla, Veera Raghava Chowdary
    Dogiparti, Dhanunjay Kumar
    Jasti, Venkat
    Atri, Alireza
    Cummings, Jeffrey
    ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, 2022, 8 (01)
  • [36] Using an Acute Drug Challenge to Predict Memantine Therapeutic Effects in Alzheimer's Disease: A Preliminary Proof of Concept and Feasibility
    Swerdlow, Neal
    Kotz, Juliana
    Talledo, Jo
    Sprock, Joyce
    Guarte, Branko
    Huege, Steven
    Romero, Jairo
    Walsh, Michael
    Delano-Wood, Lisa
    Light, Gregory
    NEUROPSYCHOPHARMACOLOGY, 2020, 45 (SUPPL 1) : 328 - 329
  • [37] A Phase 2, Randomized, Multicenter, Placebo-Controlled, Proof-of-Concept Trial of Oral Fexinidazole in Adults With Chronic Indeterminate Chagas Disease
    Torrico, Faustino
    Gascon, Joaquim
    Ortiz, Lourdes
    Pinto, Jimy
    Rojas, Gimena
    Palacios, Alejandro
    Barreira, Fabiana
    Blum, Bethania
    Schijman, Alejandro Gabriel
    Vaillant, Michel
    Strub-Wourgaft, Nathalie
    Pinazo, Maria Jesus
    Bilbe, Graeme
    Ribeiro, Isabela
    CLINICAL INFECTIOUS DISEASES, 2023, 76 (03) : E1186 - E1194
  • [38] Harnessing explainable artificial intelligence for patient-to-clinical-trial matching: A proof-of-concept pilot study using phase I oncology trials
    Ghosh, Satanu
    Abushukair, Hassan Mohammed
    Ganesan, Arjun
    Pan, Chongle
    Naqash, Abdul Rafeh
    Lu, Kun
    PLOS ONE, 2024, 19 (10):
  • [39] SYK antagonism in hidradenitis suppurativa demonstrates clinical efficacy with grearter response in B-cell predominant disease: Results of a open-label, proof-of-concept phase 2 clinical trial
    Jepsen, R.
    Flora, A.
    Kozera, E.
    Frew, J. W.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2023, 143 (09) : B15 - B15
  • [40] Classification of Patients with Alzheimer's Disease and Dementia with Lewy Bodies using Resting EEG Selected Features at Sensor and Source Levels: A Proof-of-Concept Study
    San-Martin, Rodrigo
    Fraga, Francisco J.
    Del Percio, Claudio
    Lizio, Roberta
    Noce, Giuseppe
    Nobili, Flavio
    Arnaldi, Dario
    D'Antonio, Fabrizia
    De Lena, Carlo
    Guntekin, Bahar
    Hanoglu, Lutfu
    Taylor, John Paul
    McKeith, Ian
    Stocchi, Fabrizio
    Ferri, Raffaele
    Onofrj, Marco
    Lopez, Susanna
    Bonanni, Laura
    Babiloni, Claudio
    CURRENT ALZHEIMER RESEARCH, 2021, 18 (12) : 956 - 969
12345