Steady-state distributions of nascent RNA for general initiation mechanisms

被引：6

作者：

Szavits-Nossan, Juraj ^{[1
]}

Grima, Ramon ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Biol Sci, Edinburgh EH9 3JH, Scotland

来源：

PHYSICAL REVIEW RESEARCH | 2023年 / 5卷 / 01期

关键词：

TRANSCRIPTION INITIATION; IN-VIVO; DYNAMICS; PROMOTER; TIME; TFIIA;

D O I：

10.1103/PhysRevResearch.5.013064

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Fluctuations in the number of nascent RNA accurately reflect transcriptional activity. However, mathematical models predicting their distributions are difficult to solve analytically due to their non-Markovian nature stemming from transcriptional elongation. Here we circumvent this problem by deriving an exact relationship between the steady-state distribution of nascent RNA and the distribution of initiation times, which can be computed for any general initiation mechanism described by a set of first-order reactions. We test our theory using simulations and live cell imaging data.

引用

页数：13

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