The benefits of hesperidin in central nervous system disorders, based on the neuroprotective effect

被引：30
|
作者：
Li, Xinyu [1 ,2 ]
Huang, Wei [3 ]
Tan, Rongrong [1 ,2 ]
Xu, Caijuan [1 ,2 ]
Chen, Xi [1 ,2 ]
Li, Sixin [1 ,2 ]
Liu, Ying [1 ,2 ]
Qiu, Huiwen [1 ,2 ]
Cao, Hui [1 ,2 ]
Cheng, Quan [4 ,5 ,6 ]
机构：
[1] Hunan Univ Chinese Med, Sch Clin Med, Dept Psychiat, Changsha, Hunan, Peoples R China
[2] Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Psychiat, Changsha, Hunan, Peoples R China
[3] Cent South Univ, Xiangya Hosp, Dept Integrated Tradit Chinese & Western Med, Changsha, Hunan, Peoples R China
[4] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Hunan, Peoples R China
[5] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China
[6] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Dept Neurosurg, Changsha, Hunan, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 159卷
关键词：
Hesperidin; CNS disorders; Mental disorders; Anti-depression; OXIDATIVE DAMAGE; HESPERETIN; TOXICITY; PATHWAY; BRAIN;
D O I：
10.1016/j.biopha.2023.114222
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Disorders of central nervous system (CNS) disorders are considered serious health issues. The most common CNS diseases include neurodegenerative diseases, mental disorders, demyelinating disease, ischemia-reperfusion injury, and neuroinflammation. As a natural phenolic compound, hesperidin is a flavanone glycoside with various biological effects. Increasing evidence show that the growth of CNS diseases is hindered by hesperidin. Here, we have reviewed the related literature on neuropharmacological mechanisms for the preventive and therapeutic effects of hesperidin on CNS diseases. Several cellular and animal models have been developed to evaluate the underlying neuropharmacological mechanisms of hesperidin. Additionally, clinical evidence has confirmed its neuroprotective function. Hesperidin exerts its neuroprotective properties by decreasing neuro-inflammatory and apoptotic pathways. Hesperidin function has been studied in preclinical models for CNS diseases, but little is known about its definite effect in humans. Hesperidin can effectively alleviate depression and improve cognition and memory. It is urgent to explore and discover clinical trials for further confirmation of the neuroprotective efficacy of hesperidin and to evaluate its safety profile.
引用
收藏
页数：6
相关论文
共 50 条
  • [41] Editorial: Proteostasis in central nervous system disorders
    Zhou, An
    Bian, Fang
    FRONTIERS IN MOLECULAR NEUROSCIENCE, 2024, 17
  • [42] Hyponatremia in patients with central nervous system disorders
    Rosner, M. H.
    INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2009, 63 (03) : 349 - 350
  • [43] Neuroactive steroids and central nervous system disorders
    Wang, MD
    Bäckström, T
    Sundström, I
    Wahlström, G
    Olsson, T
    Zhu, D
    Johansson, IM
    Björn, I
    Bixo, M
    NEUROSTEROIDS AND BRAIN FUNCTION, 2001, 46 : 421 - 459
  • [44] Purinergic signalling and disorders of the central nervous system
    Burnstock, Geoffrey
    NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (07) : 575 - 590
  • [45] Treatment of depression in disorders of the central nervous system
    Schmitt, L
    Camus, V
    Raynaud, JP
    ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE, 1995, 21 : 15 - 18
  • [46] CENTRAL NERVOUS SYSTEM INVOLVEMENT IN THE DISORDERS OF COLLAGEN
    LEWIS, BI
    SINTON, DW
    KNOTT, JR
    JOURNAL OF CLINICAL INVESTIGATION, 1953, 32 (06): : 583 - 584
  • [47] FAB FRAGMENTS IN CENTRAL NERVOUS SYSTEM DISORDERS
    KOLAR, O
    ZEITSCHRIFT FUR IMMUNITATS-FORSCHUNG ALLERGIE UND KLINISCHE IMMUNOLOGIE, 1968, 136 (04): : 329 - &
  • [48] Genetics of central nervous system developmental disorders
    Naegele, JR
    Lombroso, PJ
    CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA, 2001, 10 (02) : 225 - +
  • [49] LIPID STORAGE DISORDERS OF CENTRAL NERVOUS SYSTEM
    LEISTYNA, JA
    AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1962, 104 (06): : 680 - +
  • [50] THE FUNDUS OF THE EYE IN DISORDERS OF THE CENTRAL NERVOUS SYSTEM
    RUCKER, CW
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1946, 131 (04): : 321 - 321
12345