Heterologous Booster Immunization Based on Inactivated SARS-CoV-2 Vaccine Enhances Humoral Immunity and Promotes BCR Repertoire Development

被引：2
|
作者：
Li, Xinghang [1 ]
Zeng, Fengyuan [1 ]
Yue, Rong [1 ]
Ma, Danjing [1 ]
Meng, Ziyan [1 ]
Li, Qi [1 ]
Zhang, Zhenxiao [1 ]
Zhang, Haobo [1 ]
Liao, Yuansheng [1 ]
Liao, Yun [1 ]
Jiang, Guorun [1 ]
Zhao, Heng [1 ]
Yu, Li [1 ]
Li, Dandan [1 ]
Zhang, Ying [1 ]
Liu, Longding [1 ]
Li, Qihan [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biol, Yunnan Key Lab Vaccine Res & Dev Severe Infect Di, Kunming 650118, Peoples R China
来源：
VACCINES | 2024年 / 12卷 / 02期
基金：
中国国家自然科学基金;
关键词：
SARS-CoV-2; vaccine; sequential immunization; B-cell receptor; humoral immunity; B-CELL RECEPTOR; COVID-19; MECHANISMS; CLONING;
D O I：
10.3390/vaccines12020120
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent studies have indicated that sequentially administering SARS-CoV-2 vaccines can result in increased antibody and cellular immune responses. In this study, we compared homologous and heterologous immunization strategies following two doses of inactivated vaccines in a mouse model. Our research demonstrates that heterologous sequential immunization resulted in more immune responses displayed in the lymph node germinal center, which induced a greater number of antibody-secreting cells (ASCs), resulting in enhanced humoral and cellular immune responses and increased cross-protection against five variant strains. In further single B-cell analysis, the above findings were supported by the presence of unique B-cell receptor (BCR) repertoires and diversity in CDR3 sequence profiles elicited by a heterologous booster immunization strategy.
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页数：18
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