Radical Hydro-Fluorosulfonylation of Propargylic Alcohols via Electron Donor-Acceptor Photoactivation

被引：9
|
作者：
Zhang, Yingyin [1 ]
Feng, Qingyuan [1 ]
Zheng, Yu [1 ]
Lu, Yanju [1 ]
Liao, Saihu [2 ]
Huang, Shenlin [1 ,3 ]
机构：
[1] Nanjing Forestry Univ, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat F, Int Innovat Ctr Forest Chem & Mat, Nanjing 210037, Jiangsu, Peoples R China
[2] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Fujian, Peoples R China
[3] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Chem Biol & Tradit Chinese Med Res, Minist Educ China, Changsha 410081, Hunan, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 07期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1021/acs.orglett.4c00010
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A radical hydro-fluorosulfonylation of propargyl alcohols with FSO2Cl is presented based on the photoactivation of the electron donor-acceptor (EDA) complex. The reaction avoids the requirement for photocatalysts, bases, hydrogen donor reagents, any other additives, and harsh conditions, enabling the facile synthesis of various functionalized gamma-hydroxy (E)-alkenylsulfonyl fluorides. These multifunctional sulfonyl fluorides can be further diversified, providing access to various privileged molecules of biological relevance.
引用
收藏
页码：1410 / 1415
页数：6
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