Alnuctamab (ALNUC; BMS-986349; CC-93269), a BCMA x CD3 T-cell engager, in patients (pts) with relapsed/refractory multiple myeloma (RRMM): latest results from a phase 1 first-in-human clinical study

被引:0
|
作者
Costa, Luciano [1 ]
Bar, Noffar [2 ]
Mateos, Maria-Victoria [3 ]
Ribas, Paz [4 ]
Hansson, Markus [5 ]
Paris, Laura [6 ]
Hofmeister, Craig [7 ]
Rodriguez-Otero, Paula
Bermudez, Maria Aranzazu [9 ]
Santoro, Armando [8 ,10 ]
Yee, Andrew [11 ]
Creignou, Maria [12 ]
Encinas, Cristina [13 ]
Cerchione, Claudio [14 ]
de la Rubia, Javier [15 ]
Oriol, Albert [16 ]
Ferstl, Barbara [17 ]
Besemer, Britta [18 ]
Chen, Jinjie [19 ]
Boss, Isaac [19 ]
Gaudy, Allison [19 ]
Hsu, Kevin [19 ]
Godwin, Colin [19 ]
San-Miguel, Jesus [20 ]
Wong, Sandy [21 ]
机构
[1] Univ Alabama Birmingham, Birmingham, AL USA
[2] Yale Univ, Sch Med, New Haven, CT USA
[3] Univ Hosp Salamanca, IBSAL, CIC, CIBERONC, Salamanca, Spain
[4] Hosp Univ Dr Peset Aleixandre, Valencia, Spain
[5] Skane Univ Hosp, Lund, Sweden
[6] ASST Papa Giovanni XXIII, Bergamo, Italy
[7] Emory Univ, Winship Canc Inst, Atlanta, GA USA
[8] Clin Univ Navarra, CIMA, CIBERONC, IDISNA, Pamplona, Spain
[9] Hosp Univ Marques Valdecilla IDIVAL, Santander, Spain
[10] IRCCS Humanitas Res Hosp, Humanitas Canc Ctr, Milan, Italy
[11] Massachusetts Gen Hosp Canc Ctr, Boston, MA USA
[12] Karolinska Univ Hosp, Stockholm, Sweden
[13] Hosp Gen Univ Gregorio Maranon HGUGM, IiSGM, Madrid, Spain
[14] Ist Scientif Romagnolo Studio & Cura Tumori IRST, Meldola, Italy
[15] Univ Hosp La Fe, Dept Hematol, Valencia, Spain
[16] Hosp Germans Trias i Pujol, Catalan Inst Oncol & Josep Carreras Inst, Badalona, Spain
[17] Friedrich Alexander Univ Erlangen Nuremberg, Erlangen, Germany
[18] Univ Tubingen Hosp, Tubingen, Germany
[19] Bristol Myers Squibb, Princeton, NJ USA
[20] Inst Invest Navarra, Ctr Invest Med Aplicada, Ctr Invest Biomed Red Canc, Canc Ctr Clin Univ Navarra, Pamplona, Spain
[21] Univ Calif San Francisco, San Francisco, CA USA
来源
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P-033
引用
收藏
页码:S52 / S53
页数:2
相关论文
共 50 条
  • [41] Long-Term Follow-Up From MajesTEC-1 of Teclistamab, a B-Cell Maturation Antigen (BCMA) x CD3 Bispecific Antibody, in Patients With Relapsed/Refractory Multiple Myeloma (RRMM)
    van de Donk, Niels
    Moreau, Philippe
    Garfall, Alfred
    Bhutani, Manisha
    Oriol, Albert
    Nooka, Ajay
    Martin, Thomas
    Rosinol, Laura
    Mateos, Maria-Victoria
    Bahlis, Nizar
    Popat, Rakesh
    Besemer, Britta
    Martinez Lopez, Joaquin
    Krishnan, Amrita
    Delforge, Michel
    Trancucci, Danielle
    Verona, Raluca
    Stephenson, Tara
    Chastain, Katherine
    Sidana, Surbhi
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 : S477 - S478
  • [42] First results from the RedirecTT-1 study with teclistamab (tec) plus talquetamab (tal) simultaneously targeting BCMA and GPRC5D in patients (pts) with relapsed/refractory multiple myeloma (RRMM)
    Cohen, Yael C.
    Morillo, Daniel
    Gatt, Moshe E.
    Sebag, Michael
    Kim, Kihyun
    Min, Chang-Ki
    Oriol, Albert
    Ocio, Enrique M.
    Yoon, Sung-Soo
    Mateos, Maria-Victoria
    Chu, Michael
    Rodriguez-Otero, Paula
    Avivi, Irit
    Guo, Yue
    Krevvata, Maria
    Peterson, Michelle R.
    Beelen, Melissa Jo
    Vanak, Jill
    Banerjee, Arnob
    Magen, Hila
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [43] Long-term follow-up from MajesTEC-1 of teclistamab, a B-cell maturation antigen (BCMA) x CD3 bispecific antibody, in patients with relapsed/refractory multiple myeloma (RRMM).
    van de Donk, Niels W. C. J.
    Moreau, Philippe
    Garfall, Alfred L.
    Bhutani, Manisha
    Oriol, Albert
    Nooka, Ajay K.
    Martin, Thomas G.
    Rosinol, Laura
    Mateos, Maria-Victoria
    Bahlis, Nizar J.
    Popat, Rakesh
    Besemer, Britta
    Martinez-Lopez, Joaquin
    Krishnan, Amrita Y.
    Delforge, Michel
    Trancucci, Danielle
    Verona, Raluca
    Stephenson, Tara
    Chastain, Katherine
    Sidana, Surbhi
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [44] First results from the RedirecTT-1 study with teclistamab (tec) plus talquetamab (tal) simultaneously targeting BCMA and GPRC5D in patients (pts) with relapsed/refractory multiple myeloma (RRMM)
    Magen, Hila
    Morillo, Daniel
    Gatt, Moshe
    Sebag, Michael
    Kim, Kihyun
    Min, Chang-Ki
    Oriol, Albert
    Ocio, Enrique
    Yoon, Sung-Soo
    Mateos, Maria-Victoria
    Chu, Michael
    Rodriguez-Otero, Paula
    Avivi, Irit
    Guo, Yue
    Krevvata, Maria
    Peterson, Michelle
    Beelen, Melissa
    Vanak, Jill
    Banerjee, Arnob
    Cohen, Yael
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 : S49 - S50
  • [45] A Phase 1, First-in-Human Study of Talquetamab, a G Protein-Coupled Receptor Family C Group 5 Member D (GPRC5D) x CD3 Bispecific Antibody, in Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM)
    Chari, Ajai
    Berdeja, Jesus G.
    Oriol, Albert
    van de Donk, Niels W. C. J.
    Rodriguez, Paula
    Askari, Elham
    Mateos, Maria-Victoria
    Minnema, Monique C.
    Verona, Raluca
    Girgis, Suzette
    Prior, Thomas
    Hilder, Brandi W.
    Russell, Jeffery
    Goldberg, Jenna D.
    Krishnan, Amrita
    BLOOD, 2020, 136
  • [46] Modakafusp Alfa (TAK-573), an Immunocytokine, Shows Clinical Activity in Patients with Relapsed/Refractory Multiple Myeloma; Updated Results from a First-in-Human Phase 1 Study
    Vogl, Dan T.
    Kaufman, Jonathan L.
    Holstein, Sarah A.
    Atrash, Shebli
    Nadeem, Omar
    Janakiram, Murali
    Suryanarayan, Kaveri
    Liu, Yuyin
    Collins, Sabrina
    Parot, Xavier
    Chaudhry, Maria
    BLOOD, 2021, 138
  • [47] Preliminary Dose-Escalation Results from a Phase 1/2 Study of GEN3014 (HexaBody®-CD38) in Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM)
    Spencer, Andrew
    Iversen, Katrine Fladeland
    Dhakal, Binod
    Creignou, Maria
    Chen, Jenny
    Hiemstra, Ida H.
    Bosgra, Sieto
    Badani, Avani
    Breij, Esther C. W.
    Brady, Lauren K.
    Sasser, A. Kate
    Malmberg, Anders
    Gregersen, Henrik
    Hansson, Markus
    Broijl, Annemiek
    Mateos, Maria-Victoria
    Plesner, Torben
    BLOOD, 2022, 140 : 7320 - 7321
  • [48] Clinical activity of P-BCMA-ALLO1, a B-cell maturation antigen (BCMA) targeted allogeneic chimeric antigen receptor T-cell (CAR-T) therapy, in relapsed refractory multiple myeloma (RRMM) patients (pts) following progression on prior BCMA targeting therapy
    Dholaria, Bhagirathbhai
    Shune, Leyla
    Kin, Andrew
    McArthur, Katherine
    Eskew, Jeff D.
    Martin, Christopher E.
    Haag, Sabrina
    McCaigue, Joanne
    Namini, Hamid
    DePrimo, Sam
    Cranert, Stacey
    Coronella, Julia
    Shedlock, Devon
    Belani, Rajesh
    CANCER RESEARCH, 2024, 84 (07)
  • [49] Updated Phase 1 Results from MonumenTAL-1: First-in-Human Study of Talquetamab, a G Protein-Coupled Receptor Family C Group 5 Member D x CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma
    Krishnan, Amrita Y.
    Minnema, Monique C.
    Berdeja, Jesus G.
    Oriol, Albert
    van de Donk, Niels W. C. J.
    Rodriguez-Otero, Paula
    Askari, Elham
    Mateos, Maria-Victoria
    Costa, Luciano J.
    Verona, Raluca I.
    Ma, Xuewen
    Girgis, Suzette
    Yang, Shiyi
    Hilder, Brandi W.
    Russell, Jeffery
    Goldberg, Jenna D.
    Chari, Ajai
    BLOOD, 2021, 138
  • [50] Updated Results From the Phase 1/2 MajesTEC-1 Study of Teclistamab, a B-Cell Maturation Antigen x CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma
    Popat, Rakesh
    Usmani, Saad Z.
    Garfall, Alfred
    van de Donk, Niels
    Nahi, Hareth
    San-Miguel, Jesus F.
    Oriol, Albert
    Nooka, Ajay
    Martin, Thomas
    Rosinol, Laura
    Chari, Ajai
    Karlin, Lionel
    Benboubker, Lotfi
    Mateos, Maria-Victoria
    Bahlis, Nizar
    Moreau, Philippe
    Besemer, Britta
    Martinez-Lopez, Joaquin
    Sidana, Surbhi
    Pei, Lixia
    Trancucci, Danielle
    Verona, Raluca
    Girgis, Suzette
    Olyslager, Yunsi
    Jaffe, Mindy
    Uhlar, Clarissa
    Stephenson, Tara
    Van Rampelbergh, Rian
    Banerjee, Arnob
    Goldberg, Jenna D.
    Kobos, Rachel
    Krishnan, Amrita
    BRITISH JOURNAL OF HAEMATOLOGY, 2022, 197 : 35 - 36