Antiosteoporosis Effect of Salidroside against Glucocorticoid-Induced Osteoporosis in Rats Via Reduction of Inflammation Reaction

Osteoporosis is a bone disease that develops when bone mass and function are altered. Salidroside shown a bone-protective action against the disease of arthritis. We investigate the bone protective effect of salidroside against glucocorticoid (dexamethasone) induced osteoporosis in rats. In silico study was performed on the estrogen alpha receptor, estrogen beta receptor and vitamin D receptor. Sprague-Dawley (SD) was divided into different groups and treated with dexamethasone (7 mg/kg) for induction the osteoporosis. The different doses of salidroside (5, 10, and 15 mg/kg) and alendronate were given to the rats for 5 weeks. The body weight, biochemical, bone microstructure, bone parameters, antioxidant and inflammatory cytokines. In silico study showed the get better comprehension salidroside against the estrogen alpha, beta and vitamin D potency at molecular level. OS group rats exhibited the declined body weight and salidroside remarkably (p < 0.001) improved the body weight. Salidroside remarkably (p < 0.001) altered the bone microstructure, bone parameters, biochemical parameters. Salidroside remarkably (p < 0.001) repressed the level of parathyroid hormones and augmented the level of 1,25-(OH)2-vitamin D 3. Salidroside remarkably (p < 0.001) boosted the level of nutrients and altered the level of antioxidant parameters and cytokines. Salidroside exhibited the antiosteoporosis effect against DEX induced osteoporosis in the rats.