Hypercalcaemia of malignancy: a case of vitamin-D-mediated hypercalcaemia in lymphoma

被引：1

作者：

Mehta, Kanchi ^{[1
]}

Awan, Maham ^{[2
]}

Devlin, Shannon ^{[3
]}

Jassal, Simerjot Kaur ^{[1
,4
]}

机构：

[1] Medicine, Med, La Jolla, CA 92093 USA

[2] Medicine, Med, San Francisco, CA USA

[3] Washington Univ St Louis, St Louis, MO USA

[4] VA San Diego Healthcare Syst, Primary Care, San Diego, CA 92161 USA

来源：

BMJ CASE REPORTS | 2024年 / 17卷 / 02期

关键词：

Geriatric medicine; Oncology; Calcium and bone;

D O I：

10.1136/bcr-2023-256126

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypercalcaemia of malignancy (HCM) is a paraneoplastic syndrome that often portends a poor prognosis. We present an extremely rare (<1%) case of HCM due to extrarenal calcitriol (1,25-(OH)(2)D) production in a patient with splenic marginal zone lymphoma. A man in his 80s presented with a 3-week history of fatigue, unsteadiness and abdominal pain, and new findings of anaemia, kidney injury and hypercalcaemia. Laboratory evaluation, bone marrow biopsy and positron emission tomography/computed tomography (PET/CT) confirmed the diagnosis of splenic marginal zone lymphoma which produced calcitriol (1,25-(OH)(2)D-3), causing the patient's hypercalcaemia.

引用

页数：3

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