Iridoid constituents from the branches of Viburnum chinshanense and their inhibitory effects on α-amylase and α-glucosidase

被引:1
|
作者
Chen, Jia [1 ]
Tang, Yiyuan [1 ]
Zhou, Hongjuan [1 ]
Shao, Jianhua [1 ]
Ji, Wei [1 ]
Yang, Mengya [1 ]
Zhao, Chunchao [1 ]
机构
[1] Yangzhou Univ, Joint Int Res Lab Agr & Agri Prod Safety, Minist Educ, Yangzhou 225009, Peoples R China
基金
中国国家自然科学基金;
关键词
Viburnum chinshanense; Adoxaceae; Iridoid; alpha-Amylase inhibition; alpha-Glucosidase inhibition;
D O I
10.1016/j.phytochem.2023.113893
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ten previously undescribed iridoid constituents, viburnshosins A-E (1-5) and viburnshosides A-E (6-10), together with one known analogue (11), were isolated from the branches of Viburnum chinshanense. Their structures were unambiguously elucidated by a comprehensive analysis of 1D and 2D NMR data, together with HRESIMS spectroscopic data. The absolute configurations of compounds 1-10 were assigned by means of the calculated ECD spectra. Interestingly, compounds 2 and 3 are the first iridoids with an unusual C-3-C-7 oxo bridge. Compounds 4, 5, and 10 displayed remarkable inhibitory effects against alpha-amylase (IC50: 38.42, 37.65, and 21.64 mu M, respectively) and alpha-glucosidase (IC50: 12.97, 19.34, and 25.71 mu M, respectively), comparable to those of the positive control acarbose (IC50: 39.75 and 23.66 mu M, respectively). The interaction modes of compounds 4 and 10 with two enzymes were analyzed by molecular modeling.
引用
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页数:12
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