Protection against severe COVID-19 after second booster dose of adapted bivalent (original/Omicron BA.4-5) mRNA vaccine in persons ≥ 60 years, by time since infection, Italy, 12 September to 11 December 2022

被引：16

作者：

Fabiani, Massimo ^{[1
]}

Mateo-Urdiales, Alberto ^{[1
]}

Sacco, Chiara ^{[1
,2
]}

Fotakis, Emmanouil Alexandros ^{[1
,2
]}

Rota, Maria Cristina ^{[1
]}

Petrone, Daniele ^{[1
]}

Bressi, Marco ^{[1
]}

Del Manso, Martina ^{[1
]}

Siddu, Andrea ^{[3
]}

Fedele, Giorgio ^{[1
]}

Stefanelli, Paola ^{[1
]}

Bella, Antonino ^{[1
]}

Riccardo, Flavia ^{[1
]}

Palamara, Anna Teresa ^{[1
]}

Rezza, Giovanni ^{[3
]}

Brusaferro, Silvio ^{[4
]}

Pezzotti, Patrizio ^{[1
]}

机构：

[1] Ist Super Sanita, Dept Infect Dis, Rome, Italy

[2] European Ctr Dis Prevent & Control, European Programme Intervent Epidemiol Training E, Stockholm, Sweden

[3] Italian Minist Hlth, Gen Directorate Prevent, Rome, Italy

[4] Ist Super Sanita, Off President, Rome, Italy

来源：

EUROSURVEILLANCE | 2023年 / 28卷 / 08期

关键词：

D O I：

10.2807/1560-7917.ES.2023.28.8.2300105

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Effectiveness against severe COVID-19 of a second booster dose of the bivalent (original/BA.4-5) mRNA vaccine 7-90 days post-administration, relative to a first booster dose of an mRNA vaccine received >= 120 days earlier, was ca 60% both in persons >= 60 years never infected and in those infected > 6 months before. Relative effectiveness in those infected 4-6 months earlier indicated no significant additional protection (10%; 95% CI: -44 to 44). A second booster vaccination 6 months after the latest infection may be warranted.

引用

页码：8 / 14

页数：7

共 12 条

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Fabiani, Massimo
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Sacco, Chiara
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Del Manso, Martina
Siddu, Andrea
Stefanelli, Paola
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[3] Bivalent BNT162b2 mRNA original/omicron BA.4-5 booster vaccination: adverse reactions and inability to work compared with the monovalent COVID-19 booster
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[7] Relative effectiveness of monovalent and bivalent mRNA boosters in preventing severe COVID-19 due to omicron BA.5 infection up to 4 months post-administration in people aged 60 years or older in Italy: a retrospective matched cohort study
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[8] COVID-19 Incidence and Mortality Among Unvaccinated and Vaccinated Persons Aged=12 Years by Receipt of Bivalent Booster Doses and Time Since Vaccination-24 US Jurisdictions, October 3, 2021-December 24, 2022
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