Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions

被引：64

作者：

Miller, Julie J. ^{[1
,2
]}

Castro, L. Nicolas Gonzalez ^{[2
,3
,4
]}

McBrayer, Samuel ^{[5
]}

Weller, Michael ^{[6
]}

Cloughesy, Timothy ^{[7
]}

Portnow, Jana ^{[8
]}

Andronesi, Ovidiu ^{[2
,9
]}

Barnholtz-Sloan, Jill S. ^{[10
]}

Baumert, Brigitta G. ^{[11
]}

Berger, Mitchell S. ^{[12
]}

Bi, Wenya Linda ^{[2
,13
]}

Bindra, Ranjit ^{[14
]}

Cahill, Daniel P. ^{[15
]}

Chang, Susan M. ^{[12
]}

Costello, Joseph F. ^{[12
]}

Horbinski, Craig ^{[16
,17
,18
]}

Huang, Raymond Y. ^{[2
,19
]}

Jenkins, Robert B. ^{[20
]}

Ligon, Keith L. ^{[2
,21
]}

Mellinghoff, Ingo K. ^{[22
]}

Nabors, L. Burt ^{[23
]}

Platten, Michael ^{[24
]}

Reardon, David A. ^{[2
,3
,4
]}

Shi, Diana D. ^{[2
,25
]}

Schiff, David ^{[26
]}

Wick, Wolfgang ^{[27
,28
]}

Yan, Hai ^{[29
]}

von Deimling, Andreas ^{[30
,31
,32
]}

van den Bent, Martin ^{[33
]}

Kaelin, William G. ^{[2
,34
]}

Wen, Patrick Y. ^{[2
,3
,4
]}

机构：

[1] Massachusetts Gen Hosp, Stephen E & Catherine Pappas Ctr Neurooncol, Boston, MA 02114 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Ctr Neurooncol, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Dept Neurol, 75 Francis St, Boston, MA 02115 USA

[5] Univ Texas Southwestern Med Ctr Dallas, Childrens Med Ctr Res Inst, 6000 Harry Hines Blvd, Dallas, TX 75235 USA

[6] Univ Hosp Zurich, Dept Neurol, Frauenklinikstr 26, CH-8091 Zurich, Switzerland

[7] UCLA, Neurooncol Program, Los Angeles, CA USA

[8] City Hope Comprehens Canc Ctr, Oncol, Duarte, CA USA

[9] Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA

[10] NCI, Informat & Data Sci IDS, Ctr Biomed Informat & Informat Technol CBIIT, Transdiv Res Program TDRP,Div Canc Epidemiol & Ge, Bethesda, MD 20892 USA

[11] Cantonal Hosp Graubunden, Inst Radiat Oncol, Chur, Switzerland

[12] Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA USA

[13] Brigham & Womens Hosp, Dept Neurosurg, 75 Francis St, Boston, MA 02115 USA

[14] Yale Sch Med, Brain Tumor Ctr, Dept Therapeut Radiol, New Haven, CT USA

[15] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02115 USA

[16] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA

[17] Northwestern Univ, Feinberg Sch Med, Dept Neurol Surg, Chicago, IL 60611 USA

[18] Northwestern Univ, Northwestern Med Malnati Brain Tumor Inst Robert, Feinberg Sch Med, Chicago, IL 60611 USA

[19] Brigham & Womens Hosp, Dept Radiol, 75 Francis St, Boston, MA 02115 USA

[20] Mayo Clin, Dept Lab Med & Pathol, Individualized Med Res, Rochester, MN 55901 USA

[21] Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA

[22] Mem Sloan Kettering Canc Ctr, Dept Neurol, Evnin Family Chair Neurooncol, 1275 York Ave, New York, NY 10021 USA

[23] Univ Alabama Birmingham, Dept Neurol, Heersink Sch Med, Birmingham, AL 35294 USA

[24] German Canc Res Ctr, CCU Neuroimmunol & Brain Tumor Immunol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

[25] Brigham & Womens Hosp, Dept Radiat Oncol, 75 Francis St, Boston, MA 02115 USA

[26] Univ Virginia Hlth Syst, Dept Neurol, Div Neurooncol, Charlottesville, VA USA

[27] German Canc Res Ctr, Program Chair Neurooncol, Natl Ctr Tumor Dis NCT, Neurooncol, Heidelberg, Germany

[28] Neurol Clin Heidelberg, Heidelberg, Germany

[29] Genetron Hlth Inc, Gaithersburg, MD 20879 USA

[30] Univ Hosp Heidelberg, Dept Neuropathol, INF 224, D-69120 Heidelberg, Germany

[31] German Canc Res Ctr, Clin Cooperat Unit Neuropathol, INF 224, D-69120 Heidelberg, Germany

[32] DKTK, INF 224, D-69120 Heidelberg, Germany

[33] Erasmus MC Canc Inst, Brain Tumour Ctr, Groene Hilledijk 301, NL-3075 EA Rotterdam, Netherlands

[34] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

来源：

NEURO-ONCOLOGY | 2023年 / 25卷 / 01期

关键词：

D-2HG; glioma; Isocitrate dehydrogenase (IDH); LOW-GRADE GLIOMAS; CENTRAL-NERVOUS-SYSTEM; MAGNETIC-RESONANCE-SPECTROSCOPY; TERT PROMOTER MUTATIONS; RESPONSE ASSESSMENT; SURGICAL RESECTION; RADIATION-THERAPY; PHASE-III; ONCOMETABOLITE; 2-HYDROXYGLUTARATE; OLIGODENDROGLIAL TUMORS;

D O I：

10.1093/neuonc/noac207

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant primary brain tumors diagnosed in patients younger than 50, constituting an important cause of morbidity and mortality. In recent years, there has been significant progress in understanding the molecular pathogenesis and biology of these tumors, sparking multiple efforts to improve their diagnosis and treatment. In this consensus review from the Society for Neuro-Oncology (SNO), the current diagnosis and management of IDH-mutant gliomas will be discussed. In addition, novel therapies, such as targeted molecular therapies and immunotherapies, will be reviewed. Current challenges and future directions for research will be discussed.

引用

页码：4 / 25

页数：22

共 24 条

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