The role of glycosylation in clinical allergy and immunology

被引：4

作者：

Hale, Rebecca C. ^{[1
,2
]}

Morais, Dominique ^{[2
]}

Chou, Janet ^{[1
,4
]}

Stowell, Sean R. ^{[2
,3
,5
]}

机构：

[1] Harvard Med Sch, Boston Childrens Hosp, Div Immunol, Boston, MA USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Joint Program Transfus Med, Boston, MA USA

[3] Harvard Med Sch, Harvard Glyc Ctr, Boston, MA 02115 USA

[4] Harvard Med Sch, Boston Childrens Hosp, Div Immunol, 10th Floor,Karp Bldg, Boston, MA 02115 USA

[5] Harvard Med Sch, Brigham & Womens Hosp, Natl Ctr Funct Glyc, Joint Program Transfus Med, 630E New Res Bldg,77 Ave Louis Pasteur, Boston, MA 02115 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2024年 / 153卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Glycosylation; immunomodulation; antibody glycosyla tion; PGM3; immunotherapy; REACTIVE CARBOHYDRATE DETERMINANTS; IMMUNE-RESPONSE; T-CELLS; ANTIINFLAMMATORY ACTIVITY; N-ACETYLGLUCOSAMINE; GLYCAN INTERACTIONS; IMMUNOGLOBULIN-G; IGE ANTIBODIES; RECEPTOR; BINDING;

D O I：

10.1016/j.jaci.2023.09.003

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

While glycans are among the most abundant macromolecules on the cell with widespread functions, their role in immunity has historically been challenging to study. This is in part due to difficulties assimilating glycan analysis into routine approaches used to interrogate immune cell function. Despite this, recent developments have illuminated fundamental roles for glycans in host immunity. The growing field of glycoimmunology continues to leverage new tools and approaches to uncover the function of glycans and glycan-binding proteins in immunity. Here we utilize clinical vignettes to examine key roles of glycosylation in allergy, inborn errors of immunity, and autoimmunity. We will discuss the diverse functions of glycans as epitopes, as modulators of antibody function, and as regulators of immune cell function. Finally, we will highlight immune modulatory therapies that harness the critical role of glycans in the immune system. (J Allergy Clin Immunol 2024;153:55-66.)

引用

页码：55 / 66

页数：12

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