The Pyridotriazole Works as a Traceless Directing Group: A C-H Activation/Annulation Cascade Reaction with Iodonium Ylides

被引：11
|
作者：
Lv, Guanghui [1 ,2 ]
Zhang, Qingyao [1 ]
Zhang, Cuimei [1 ]
Chen, Yuting [1 ]
Lin, Zheng [1 ]
Lai, Ruizhi [1 ]
Yang, Zhongzhen [1 ]
Wu, Yong [1 ]
机构：
[1] Sichuan Univ, West China Sch Pharm, Dept Med Chem, Key Lab Drug Targeting, Chengdu 610041, Sichuan, Peoples R China
[2] Hubei Univ Med, Taihe Hosp, Dept Pharm, Shiyan 442000, Hubei, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 22期
关键词：
CATALYZED DENITROGENATIVE TRANSANNULATION; ACTIVATION; ACCESS; ALKYNES; ANHYDROEXFOLIAMYCIN; REARRANGEMENT; METABOLITE; CARBENES; NITRONES; ARYL;
D O I：
10.1021/acs.orglett.3c01102
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel Rh-catalyzed cascade reaction of pyridotriazoleswith iodoniumylides is reported. This one-pot procedure involves a triazole-directed ortho-position C-H carbene insertion, followed byintramolecular denitrogenation annulation. It was noteworthy thatthis reaction provided straightforward access to 1H-isochromene frameworks with excellent yields (up to 94% yield).
引用
收藏
页码：4022 / 4027
页数：6
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