Rh(iii)-catalyzed C-H annulation of sulfoxonium ylides with iodonium ylides towards isocoumarins

被引：29
|
作者：
Yin, Chuanliu [1 ]
Li, Lianghao [1 ]
Yu, Chuanming [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 05期
基金：
中国国家自然科学基金;
关键词：
HYDRANGEAE-DULCIS FOLIUM; CYCLIZATION; ANTIFUNGAL; ACTIVATION; STRATEGIES; CARBENES; INDOLES; ACCESS;
D O I：
10.1039/d1ob02273c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The direct synthesis of isocoumarin skeletons has been realized through the Rh(iii)-catalyzed [3 + 3] annulation of sulfoxonium ylides with iodonium carbenes. The synthetic protocol was constructed efficiently with broad functional group tolerance and mild reaction conditions. This reaction can be formally viewed as the result of C-H activation, carbene insertion and nucleophilic addition processes. Furthermore, the further conversions of the product and gram-scale reactions were also demonstrate to support the effectiveness of the synthesis protocol.
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页码：1112 / 1116
页数：5
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